Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 168008..168615 Replicon chromosome
Accession NZ_CP056129
Organism Enterobacter roggenkampii strain RHBSTW-00925

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H0N5B9
Locus tag HV328_RS00790 Protein ID WP_071993467.1
Coordinates 168008..168193 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A155E9Y3
Locus tag HV328_RS00795 Protein ID WP_032675741.1
Coordinates 168208..168615 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV328_RS00775 164440..165978 + 1539 WP_023617402.1 aldehyde dehydrogenase AldB -
HV328_RS00780 165975..166940 - 966 WP_063435980.1 LysR family transcriptional regulator -
HV328_RS00785 167058..167798 + 741 WP_021242443.1 MipA/OmpV family protein -
HV328_RS00790 168008..168193 + 186 WP_071993467.1 type II toxin-antitoxin system HicA family toxin Toxin
HV328_RS00795 168208..168615 + 408 WP_032675741.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HV328_RS00800 168619..169695 - 1077 Protein_158 type I restriction enzyme HsdR N-terminal domain-containing protein -
HV328_RS00805 170041..170736 - 696 WP_047745813.1 L-ribulose-5-phosphate 4-epimerase -
HV328_RS00810 170730..171590 - 861 WP_047745811.1 L-ribulose-5-phosphate 3-epimerase -
HV328_RS00815 171593..172246 - 654 WP_047745809.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6882.06 Da        Isoelectric Point: 11.2341

>T162697 WP_071993467.1 NZ_CP056129:168008-168193 [Enterobacter roggenkampii]
VKSADVITVLISHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T162697 NZ_CP071955:3415650-3416300 [Xanthomonas fragariae]
ATGTCTAGGCGCTATCCCAACCTCAACCCAGACAAAGCCCTGATCTGGCGCATCGTCCATCGCGACAACCTGCCTTGGAT
TATGGACAACGGCCTGCACTGCGGTAATGGCGGGGTGCAGAGCCCAGGCTGGGTGAGCATCGGCAATCCGGAATTGATCG
CCAAACGCGCCAATCATCCTGTGCCGCTCGCACCGGGTGGCTTCCTGAACGATTACGTGCCTTTCTACTTCACTCCATTT
TCGCCGATGCTGCGCAACATCCATACCGGCTGGGGAGGTATCCAACGACGGTCGAACGAGGAGATTGTGATACTTGTTTC
TAGCCTGCATCATGTCGCGGCACGAGGATGGCTTTTCCTGTTCACCGATAGTCACGCTGACTATCAGTTAACAACTTTCC
ATTCCGATTTGGCCAACCTCTGCAAGATCGACTGGCCATTGCTTCAAGCGCGCGATTTTCGGCGCGATCAGGAGGACCCG
GCCAAGTTCGAGCGATATCAGGCGGAAGCACTGGTTCACCGACACTTGCCAATCGATGGCCTGCGCGGCATCGTGGGTTA
TACGGACGATATGAAGCTGTCCATCGAGCGTCAACTTAAGGCTCGCAACCTCACACTTCCAGTTCATGCCCGCCCCGAGT
GGTACTTCTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15010.78 Da        Isoelectric Point: 4.3897

>AT162697 WP_032675741.1 NZ_CP056129:168208-168615 [Enterobacter roggenkampii]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDNALPLPGNVEAHLESRPEDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPG

Download         Length: 408 bp

>AT162697 NZ_CP071955:3416339-3417370 [Xanthomonas fragariae]
GTGGAGGCATTGGTCAACACTGTCAACACCGTCGGCGTGATGGGCAAAGGCATCGCGCTGATGTTCAAGGAGCGCTTCAA
CGAAAACTTCCTCCGATATGCCGCTGCCTGCAAGGCAAAGCAGGTGCGCACGGGCAAGGTGTTCGTCACCGAAGCCAACG
AACTGGACGGGCCACGCTGGATCATCAATTTTCCGACAAAACAGCACTGGCGTGGCGATTCGCGCATCGAATGGATCACC
GAAGGGCTGCAGGATCTGCGCCTCTTCCTGATCGAGAACAAGGTCGGATCGATTGCCATCCCGCCACTGGGCGCCGGCAA
TGGCGGGTTGGACTGGGCTGACGTGCGTCCACTGATCGAAGAGTCGCTGGCCGGTCTGGATACCGACATTTTCGTGTTCG
AGCCTACCCTGAAGTATCAAAACGTCGCAAAGCGCTCCGGCGTGGAGACGCTGACTCCAGCACGCGCTTTGATTGCCGAA
CTGGTACGTCGCTATTGGGTGCTAGGCGTGGAATGCAGCCTGTTGGAAATCCAGAAGCTGGCATGGTTTCTTGAACGCAA
CATCGAGCGCGCAGGCTTGCCTACGCTGGATTTGCGCTTTGCGCCAAACAAATATGGCCCATATGCCGACCGTCTCCGCC
ATCTGCTGGACGGGCTGGACGGAAGCTATCTGCACTGTGACAAGCGAATCGGCGACGCTGATCCTATAGATGTCATCTGG
TTCGATGACGCTCGCAAAAGCGTTGTCCATGCCTATCTCAAGAGCGAAGCAAAACAGTATGCTCCAGCACTGGAAGCCAC
TGCCGCCTTGATCGATGGTTTTGAAACCCCTTTTGGCATGGAGTTGCTGGCAACGGTGGACTGGCTAATTGCGCAGGGGG
GTGTCTGTCCGCAAGTGGCAGACATGCGCGAGGGCATACGCAACTGGCCCGGTGGCGCTGACGCAGCTGTGCGGAAAGAC
AGATTGTTCGATGACCGCGCTCTAGGCATCGCGTTGGAACGACTGACATCAAGTGCAAGCGCAGTGACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0N5B9

Antitoxin

Source ID Structure
AlphaFold DB A0A155E9Y3

References