Detailed information of TA system TA162694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-RHH
• Location: 4508898..4509514
• Replicon: chromosome
• Accession: NZ_CP056126
• Organism: Enterobacter asburiae strain RHBSTW-01009

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HV349_RS22225
• Protein ID: WP_081051446.1
• Coordinates: 4508898..4509269 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A376FEL2
• Locus tag: HV349_RS22230
• Protein ID: WP_029741590.1
• Coordinates: 4509272..4509514 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV349_RS22210	4506398..4507300	+	903	WP_008501831.1	formate dehydrogenase subunit beta	-
HV349_RS22215	4507297..4507932	+	636	WP_010436852.1	formate dehydrogenase cytochrome b556 subunit	-
HV349_RS22220	4507929..4508858	+	930	WP_029741588.1	formate dehydrogenase accessory protein FdhE	-
HV349_RS22225	4508898..4509269	-	372	WP_081051446.1	type II toxin-antitoxin system VapC family toxin	Toxin
HV349_RS22230	4509272..4509514	-	243	WP_029741590.1	ribbon-helix-helix domain-containing protein	Antitoxin
HV349_RS22235	4509714..4510634	+	921	WP_181599593.1	alpha/beta hydrolase	-
HV349_RS22240	4510643..4511584	-	942	WP_059347397.1	fatty acid biosynthesis protein FabY	-
HV349_RS22245	4511629..4512066	-	438	WP_008501836.1	D-tyrosyl-tRNA(Tyr) deacylase	-
HV349_RS22250	4512063..4512944	-	882	WP_047646947.1	virulence factor BrkB family protein	-
HV349_RS22255	4512938..4513537	-	600	WP_029740331.1	glucose-1-phosphatase	-
HV349_RS22260	4513626..4514096	-	471	WP_181599594.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-109)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-49)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13589.71 Da
• Isoelectric Point: 6.9789

>T162694 WP_081051446.1 NZ_CP056126:c4509269-4508898 [Enterobacter asburiae]
MEHMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEAKTAAVMGAFEIIDISRDIAERSVLLR
EKHGMKLPDAIILATAQSRSCPLISRNTKDFSGITGVVSPYQL

Nucleotide

• Length: 372 bp

>T162694 NZ_CP071955:c1023132-1022641 [Xanthomonas fragariae]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCTTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCGACCGGTGCGTCACGGACCGTCGTTGCCTGCGCGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCAGACCCG
ATCCCCGTGGTGGTGCTTGGCAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGGTGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTTGAGCCCTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9401.51 Da
• Isoelectric Point: 4.1735

>AT162694 WP_029741590.1 NZ_CP056126:c4509514-4509272 [Enterobacter asburiae]
MSLSADLDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Nucleotide

• Length: 243 bp

>AT162694 NZ_CP071955:c1023419-1023129 [Xanthomonas fragariae]
ATGTCCACACCCAACACTACGCCCGGCAAGCGCGAAACCTTGAATCTGCGCATCAAGCCGGAGGAGCGCAGTCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCGCGGCCAGCCCGGACGCCTACGCCGCCTTCTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A376FEL2