Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3925009..3925688 Replicon chromosome
Accession NZ_CP056126
Organism Enterobacter asburiae strain RHBSTW-01009

Toxin (Protein)


Gene name ykfI Uniprot ID A0A1Z3N0J5
Locus tag HV349_RS19335 Protein ID WP_045268641.1
Coordinates 3925009..3925350 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A1Z3N0L6
Locus tag HV349_RS19340 Protein ID WP_045268640.1
Coordinates 3925371..3925688 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV349_RS19315 3920292..3922037 + 1746 WP_029741754.1 DNA primase -
HV349_RS19320 3922191..3924038 + 1848 WP_023309228.1 RNA polymerase sigma factor RpoD -
HV349_RS19325 3924140..3924646 - 507 WP_029741755.1 G/U mismatch-specific DNA glycosylase -
HV349_RS19335 3925009..3925350 - 342 WP_045268641.1 TA system toxin CbtA family protein Toxin
HV349_RS19340 3925371..3925688 - 318 WP_045268640.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV349_RS19345 3925708..3925929 - 222 WP_007893437.1 DUF987 domain-containing protein -
HV349_RS19350 3925938..3926414 - 477 WP_000811693.1 RadC family protein -
HV349_RS19355 3926430..3926888 - 459 WP_000211838.1 antirestriction protein -
HV349_RS19360 3926986..3927225 - 240 WP_000194654.1 DUF905 domain-containing protein -
HV349_RS19365 3927304..3927771 - 468 WP_058673476.1 hypothetical protein -
HV349_RS19370 3927794..3928237 - 444 WP_181599552.1 hypothetical protein -
HV349_RS19375 3928237..3928473 - 237 WP_001115854.1 hypothetical protein -
HV349_RS19380 3928510..3929211 - 702 WP_164692006.1 WYL domain-containing protein -
HV349_RS19385 3929428..3930249 - 822 Protein_3792 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13045.30 Da        Isoelectric Point: 10.5786

>T162693 WP_045268641.1 NZ_CP056126:c3925350-3925009 [Enterobacter asburiae]
MKTLPATTLRVVKPCLSPVAIWKMLLTRLLEQHYGLTLNDTPFSKERVIQEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRKNLVR

Download         Length: 342 bp

>T162693 NZ_CP071955:529656-529790 [Xanthomonas fragariae]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTTTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCTGGCGAGAAAGTGGAAGACGCTGCGCGCAAGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11976.67 Da        Isoelectric Point: 6.7379

>AT162693 WP_045268640.1 NZ_CP056126:c3925688-3925371 [Enterobacter asburiae]
MTHIIWGLQRNITPRLGARLVQEGNRLHYLADRASITGMFSDVECLKLDDTFQHFIRQMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT162693 NZ_CP071955:529424-529576 [Xanthomonas fragariae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGTCGGCGTGATGACTGGCTGTAACACCGTTGCTGGCGC
CGGCAAGGACATCCAACGCGCGGGCAGCAAGGTCGAAAAGAAGGCCGATAACTGCAGCGACGGTAAATGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z3N0J5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3N0L6

References