Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3699338..3699995 Replicon chromosome
Accession NZ_CP056126
Organism Enterobacter asburiae strain RHBSTW-01009

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag HV349_RS18195 Protein ID WP_021242050.1
Coordinates 3699338..3699748 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag HV349_RS18200 Protein ID WP_010435322.1
Coordinates 3699729..3699995 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV349_RS18175 3695331..3697064 - 1734 WP_059347710.1 single-stranded-DNA-specific exonuclease RecJ -
HV349_RS18180 3697070..3697783 - 714 WP_029740340.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV349_RS18185 3697812..3698708 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
HV349_RS18190 3698810..3699331 + 522 WP_059347709.1 flavodoxin FldB -
HV349_RS18195 3699338..3699748 - 411 WP_021242050.1 protein YgfX Toxin
HV349_RS18200 3699729..3699995 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
HV349_RS18205 3700290..3701270 + 981 WP_054830214.1 tRNA-modifying protein YgfZ -
HV349_RS18210 3701346..3702005 - 660 WP_023309101.1 hemolysin III family protein -
HV349_RS18215 3702171..3702482 - 312 WP_054830213.1 N(4)-acetylcytidine aminohydrolase -
HV349_RS18220 3702534..3703265 + 732 WP_029739204.1 MurR/RpiR family transcriptional regulator -
HV349_RS18225 3703382..3704815 + 1434 WP_059347708.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T162692 WP_021242050.1 NZ_CP056126:c3699748-3699338 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T162692 NZ_CP071955:529424-529576 [Xanthomonas fragariae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGTCGGCGTGATGACTGGCTGTAACACCGTTGCTGGCGC
CGGCAAGGACATCCAACGCGCGGGCAGCAAGGTCGAAAAGAAGGCCGATAACTGCAGCGACGGTAAATGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT162692 WP_010435322.1 NZ_CP056126:c3699995-3699729 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT162692 NZ_CP071955:529656-529790 [Xanthomonas fragariae]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTTTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCTGGCGAGAAAGTGGAAGACGCTGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References