Detailed information of TA system TA162679

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 2240705..2241213
• Replicon: chromosome
• Accession: NZ_CP056123
• Organism: Moritella sp. 24

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HWV00_RS10025
• Protein ID: WP_211686116.1
• Coordinates: 2240953..2241213 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: B6ERH5
• Locus tag: HWV00_RS10020
• Protein ID: WP_012551877.1
• Coordinates: 2240705..2240956 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWV00_RS10005 (HWV00_10005)	2236773..2237354	-	582	WP_211686110.1	TetR/AcrR family transcriptional regulator	-
HWV00_RS10010 (HWV00_10010)	2237536..2238588	+	1053	WP_211686112.1	alkene reductase	-
HWV00_RS10015 (HWV00_10015)	2238894..2240573	+	1680	WP_211686114.1	methyl-accepting chemotaxis protein	-
HWV00_RS10020 (HWV00_10020)	2240705..2240956	+	252	WP_012551877.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HWV00_RS10025 (HWV00_10025)	2240953..2241213	+	261	WP_211686116.1	Txe/YoeB family addiction module toxin	Toxin
HWV00_RS10030 (HWV00_10030)	2242572..2244224	-	1653	WP_211686118.1	glycoside hydrolase family 19 protein	-
HWV00_RS10035 (HWV00_10035)	2244731..2245186	-	456	WP_211686120.1	TerB family tellurite resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	flmH	2044821..2404798	359977

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10269.67 Da
• Isoelectric Point: 9.4243

>T162679 WP_211686116.1 NZ_CP056123:2240953-2241213 [Moritella sp. 24]
MSRMLAWTDEAWSDYLYWQGQDKKTLKRINRLITDTKRSAFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVNDTHLTII
SCRYHY

Nucleotide

• Length: 261 bp

>T162679 NZ_CP071954:c2652686-2652510 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9189.31 Da
• Isoelectric Point: 4.6683

>AT162679 WP_012551877.1 NZ_CP056123:2240705-2240956 [Moritella sp. 24]
MRIVSFTEARNGLKSVLDGVVNDADCTVITRRDSEDAVVMSMDYYNSLMETIYLSRSPANAAHLNKSIAQYNAGQTTERG
LLE

Nucleotide

• Length: 252 bp

>AT162679 NZ_CP071954:c2652464-2652048 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1B9PEW0