Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2240705..2241213 Replicon chromosome
Accession NZ_CP056123
Organism Moritella sp. 24

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag HWV00_RS10025 Protein ID WP_211686116.1
Coordinates 2240953..2241213 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID B6ERH5
Locus tag HWV00_RS10020 Protein ID WP_012551877.1
Coordinates 2240705..2240956 (+) Length 84 a.a.

Genomic Context

HWV00_RS10010HWV00_RS10015HWV00_RS10020HWV00_RS10025HWV00_RS10005HWV00_RS10030HWV00_RS10035
Location: 2237536..2238588 (1053 bp)
Type: Others
Protein ID: WP_211686112.1
Location: 2238894..2240573 (1680 bp)
Type: Others
Protein ID: WP_211686114.1
Location: 2240705..2240956 (252 bp)
Type: Antitoxin
Protein ID: WP_012551877.1
Location: 2240953..2241213 (261 bp)
Type: Toxin
Protein ID: WP_211686116.1
Location: 2236773..2237354 (582 bp)
Type: Others
Protein ID: WP_211686110.1
Location: 2242572..2244224 (1653 bp)
Type: Others
Protein ID: WP_211686118.1
Location: 2244731..2245186 (456 bp)
Type: Others
Protein ID: WP_211686120.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HWV00_RS10005 (HWV00_10005)2236773..2237354-582WP_211686110.1TetR/AcrR family transcriptional regulator-
HWV00_RS10010 (HWV00_10010)2237536..2238588+1053WP_211686112.1alkene reductase-
HWV00_RS10015 (HWV00_10015)2238894..2240573+1680WP_211686114.1methyl-accepting chemotaxis protein-
HWV00_RS10020 (HWV00_10020)2240705..2240956+252WP_012551877.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
HWV00_RS10025 (HWV00_10025)2240953..2241213+261WP_211686116.1Txe/YoeB family addiction module toxinToxin
HWV00_RS10030 (HWV00_10030)2242572..2244224-1653WP_211686118.1glycoside hydrolase family 19 protein-
HWV00_RS10035 (HWV00_10035)2244731..2245186-456WP_211686120.1TerB family tellurite resistance protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element-flmH2044821..2404798359977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10269.67 Da        Isoelectric Point: 9.4243

>T162679 WP_211686116.1 NZ_CP056123:2240953-2241213 [Moritella sp. 24]
MSRMLAWTDEAWSDYLYWQGQDKKTLKRINRLITDTKRSAFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVNDTHLTII
SCRYHY

Download         Length: 261 bp

>T162679 NZ_CP071954:c2652686-2652510 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9189.31 Da        Isoelectric Point: 4.6683

>AT162679 WP_012551877.1 NZ_CP056123:2240705-2240956 [Moritella sp. 24]
MRIVSFTEARNGLKSVLDGVVNDADCTVITRRDSEDAVVMSMDYYNSLMETIYLSRSPANAAHLNKSIAQYNAGQTTERG
LLE

Download         Length: 252 bp

>AT162679 NZ_CP071954:c2652464-2652048 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1B9PEW0

References