Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 970300..972068 Replicon chromosome
Accession NZ_CP056123
Organism Moritella sp. 24

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag HWV00_RS04450 Protein ID WP_255554908.1
Coordinates 970300..971001 (+) Length 234 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag HWV00_RS04455 Protein ID WP_211684941.1
Coordinates 971001..972068 (+) Length 356 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWV00_RS04430 (HWV00_04430) 966087..966476 + 390 WP_211684939.1 hypothetical protein -
HWV00_RS04435 (HWV00_04435) 966533..966847 + 315 WP_211686742.1 SHOCT domain-containing protein -
HWV00_RS04440 (HWV00_04440) 967027..968685 - 1659 WP_211684940.1 hypothetical protein -
HWV00_RS04445 (HWV00_04445) 969056..970065 + 1010 Protein_814 ribosome small subunit-dependent GTPase A -
HWV00_RS04450 (HWV00_04450) 970300..971001 + 702 WP_255554908.1 DUF4433 domain-containing protein Toxin
HWV00_RS04455 (HWV00_04455) 971001..972068 + 1068 WP_211684941.1 macro domain-containing protein Antitoxin
HWV00_RS04460 (HWV00_04460) 972311..972712 - 402 WP_211684942.1 hypothetical protein -
HWV00_RS04465 (HWV00_04465) 972952..973965 + 1014 WP_211684943.1 DUF2235 domain-containing protein -
HWV00_RS04470 (HWV00_04470) 974043..975605 - 1563 WP_211684944.1 phospholipase D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(33-233)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 234 a.a.        Molecular weight: 27072.93 Da        Isoelectric Point: 8.8812

>T162678 WP_255554908.1 NZ_CP056123:970300-971001 [Moritella sp. 24]
MLQLPDCEQKAVYRKIMSYDYSQSINPKKALIWRIVHRDNLPWIFANGLHSGNSSTQSKKWVHIGNPELTSKRASHPVPI
VPNGFLNDYVPFYFTPFSVMLKNIHGGRGGVKQRHNDEIVILVSSVHKIKNLGLDFVFTDSHAYYRWATYYNEVKDLDKI
DWSLLQQRDFKRDADDPAKFERYQAEALVHGSCPIDALLGIICYSEKTKTDIDKLLIERNMNLDVYARTGWYF

Download         Length: 702 bp

>T162678 NZ_CP071954:2547724-2549046 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
TGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGGAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGGTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGCCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 356 a.a.        Molecular weight: 40166.70 Da        Isoelectric Point: 6.3606

>AT162678 WP_211684941.1 NZ_CP056123:971001-972068 [Moritella sp. 24]
MIKYVEGNLLEAPVEALVNTVNTVGVMGKGIALMFKESFPKNMKEYAQACKAKDVVTGKMFVTQTHDFLGPQWIVNFPTK
QHWRSKSKMEWIEDGLDDLRLFITTNNVKSIAIPPLGAGHGGLQWEDVKTRIVNKLSDLEDVEILIFTPTTKYQNVVKKE
GVETLTPARAMIAELIRQYWVLGMECSLLEIQKLAWFLQRVINSMEIKDPLKLQFEPHLYGPYANNLSHLLNAIDGSYLK
SDKRIPDASPLDVVCFDDSKKDILSLYLKTEAQAYLPALKKATQIIDGFESPFGMELLSTVDWLIVEEGCEPTLSGIRQG
MNNWPAGNKWALRKSKLFDDRSILFALEQLAINKL

Download         Length: 1068 bp

>AT162678 NZ_CP071954:2547458-2547724 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References