Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1563441..1565030 Replicon chromosome
Accession NZ_CP056120
Organism Moritella sp. 36

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HWV03_RS07170 Protein ID WP_211679095.1
Coordinates 1563714..1565030 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HWV03_RS07165 Protein ID WP_211676288.1
Coordinates 1563441..1563713 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWV03_RS07145 (HWV03_07135) 1560353..1561216 - 864 WP_211679093.1 EamA family transporter -
HWV03_RS07150 (HWV03_07140) 1561362..1562069 - 708 WP_045111034.1 AraC family transcriptional regulator -
HWV03_RS07155 (HWV03_07145) 1562734..1563003 + 270 WP_211679094.1 hypothetical protein -
HWV03_RS07160 (HWV03_07150) 1563006..1563218 - 213 WP_255547106.1 TOBE domain-containing protein -
HWV03_RS07165 (HWV03_07155) 1563441..1563713 + 273 WP_211676288.1 helix-turn-helix domain-containing protein Antitoxin
HWV03_RS07170 (HWV03_07160) 1563714..1565030 + 1317 WP_211679095.1 type II toxin-antitoxin system HipA family toxin Toxin
HWV03_RS07175 (HWV03_07165) 1565052..1566140 - 1089 WP_211680073.1 molybdenum ABC transporter ATP-binding protein ModC -
HWV03_RS07180 (HWV03_07170) 1566140..1566832 - 693 WP_255547107.1 molybdate ABC transporter permease subunit -
HWV03_RS07185 (HWV03_07175) 1566844..1567641 - 798 WP_211679096.1 molybdate ABC transporter substrate-binding protein -
HWV03_RS07190 (HWV03_07180) 1567779..1568939 - 1161 WP_211679097.1 diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(3-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 48767.96 Da        Isoelectric Point: 7.5047

>T162677 WP_211679095.1 NZ_CP056120:1563714-1565030 [Moritella sp. 36]
MEKLNVAMNGYFVGTLFKTTTGAHTFSYSPDWLAQPGARPISLSLPLRTAVFKGDAVFNFFDNLLPDNNQVRDRVVARHG
AHSNQPFDLLAKIGRDSVGALQIYPPNELPADITHIEAKPLDDNGVARILNGYQSAAPLGMIEDEDEFRISIAGAQEKTA
LLKIAEQWYLPLGSTPTTHILKLPIGTIQSHSFSIDLSDSVENELVCMLLAKEYGLDTADCSILNVEGVKALAIKRFDRK
PSENKQWIIRLPQEDFCQVLNVSSGRKYEQDGGPGIKDIMQYLLSSDRPTHDRSEFMKAQVLFWLLAASDGHAKNFSVFI
KAGGGYQLTPLYDIISTYPLMGGNGIRPQKVKLAMGLYTSKEGSQARKYNWQQLFPRHFMATAKVVGFSDAEMQQILINF
KIKTPQVIERVREQLPSDFPKLISEAIFNGVTKMAARL

Download         Length: 1317 bp

>T162677 NZ_CP071954:2232556-2232659 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10005.40 Da        Isoelectric Point: 5.8375

>AT162677 WP_211676288.1 NZ_CP056120:1563441-1563713 [Moritella sp. 36]
MKITSAKQLANALQDTRKTKALSQTDVAKQVGIRQDTVSKFELNPDSTKLDTLFKMLAALNLELHVAPRGEGLPEDVENV
QTPAGWKEEW

Download         Length: 273 bp

>AT162677 NZ_CP071954:c2232697-2232426 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References