Detailed information of TA system TA162668

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3244465..3245248
• Replicon: chromosome
• Accession: NZ_CP056119
• Organism: Enterobacter ludwigii strain D42-sc-1712201

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HWQ18_RS15555
• Protein ID: WP_167353669.1
• Coordinates: 3244465..3244833 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HWQ18_RS15560
• Protein ID: WP_040018969.1
• Coordinates: 3244889..3245248 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWQ18_RS15535	3240408..3241310	-	903	WP_004114645.1	bacteriophage abortive infection AbiH family protein	-
HWQ18_RS15540	3241397..3242314	+	918	WP_176587110.1	hypothetical protein	-
HWQ18_RS15545	3242937..3243926	+	990	WP_004114642.1	glycosyltransferase	-
HWQ18_RS15550	3244065..3244385	+	321	WP_004114640.1	hypothetical protein	-
HWQ18_RS15555	3244465..3244833	-	369	WP_167353669.1	TA system toxin CbtA family protein	Toxin
HWQ18_RS15560	3244889..3245248	-	360	WP_040018969.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HWQ18_RS15565	3245271..3245492	-	222	WP_004114632.1	DUF987 domain-containing protein	-
HWQ18_RS15570	3245506..3245988	-	483	WP_004114630.1	DNA repair protein RadC	-
HWQ18_RS15575	3245985..3246218	-	234	WP_040018970.1	hypothetical protein	-
HWQ18_RS15580	3246229..3246708	-	480	WP_040018971.1	antirestriction protein	-
HWQ18_RS15585	3246788..3247609	-	822	WP_163594411.1	DUF945 domain-containing protein	-
HWQ18_RS15590	3247720..3247932	-	213	WP_040018973.1	hypothetical protein	-
HWQ18_RS15595	3248018..3248377	-	360	WP_004114622.1	hypothetical protein	-
HWQ18_RS15600	3248432..3248896	-	465	WP_004114621.1	hypothetical protein	-
HWQ18_RS15605	3249174..3250031	-	858	WP_163594414.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3227153..3267092	39939

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (7-110)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13601.52 Da
• Isoelectric Point: 9.4643

>T162668 WP_167353669.1 NZ_CP056119:c3244833-3244465 [Enterobacter ludwigii]
IQSLPPQRAASSRLSSVEIWQKLLEYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGFSV
KEQSPFIGSLDMLRARKATGLMTRKGYKTVTDITGGRFSGGK

Nucleotide

• Length: 369 bp

>T162668 NZ_CP071954:217120-217227 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13349.56 Da
• Isoelectric Point: 8.1516

>AT162668 WP_040018969.1 NZ_CP056119:c3245248-3244889 [Enterobacter ludwigii]
MKKATRIINHNIAEPWWGLRRNITPCLGARLVQEGNRLHYLADRASIAGTFNDTDLRHLDQAFPVLMKQMELMLASSELT
PHIQRCITLHAKGLICEADTLGSCGYLYIVIYPTSAITA

Nucleotide

• Length: 360 bp

>AT162668 NZ_CP071954:c217071-217008 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT