Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2930850..2931507 Replicon chromosome
Accession NZ_CP056119
Organism Enterobacter ludwigii strain D42-sc-1712201

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag HWQ18_RS14045 Protein ID WP_014171514.1
Coordinates 2931097..2931507 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HWQ18_RS14040 Protein ID WP_003863437.1
Coordinates 2930850..2931116 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ18_RS14020 2926257..2927690 - 1434 WP_020883728.1 6-phospho-beta-glucosidase BglA -
HWQ18_RS14025 2927807..2928538 - 732 WP_020883729.1 MurR/RpiR family transcriptional regulator -
HWQ18_RS14030 2928805..2929464 + 660 WP_014171517.1 hemolysin III family protein -
HWQ18_RS14035 2929575..2930555 - 981 WP_020883730.1 tRNA-modifying protein YgfZ -
HWQ18_RS14040 2930850..2931116 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HWQ18_RS14045 2931097..2931507 + 411 WP_014171514.1 protein YgfX Toxin
HWQ18_RS14050 2931514..2932035 - 522 WP_032680333.1 flavodoxin FldB -
HWQ18_RS14055 2932137..2933033 + 897 WP_014171511.1 site-specific tyrosine recombinase XerD -
HWQ18_RS14060 2933057..2933770 + 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HWQ18_RS14065 2933776..2935509 + 1734 WP_032680335.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T162667 WP_014171514.1 NZ_CP056119:2931097-2931507 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T162667 NZ_CP071954:216637-216744 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT162667 WP_003863437.1 NZ_CP056119:2930850-2931116 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT162667 NZ_CP071954:c216588-216525 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References