Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1436441..1436957 Replicon chromosome
Accession NZ_CP056119
Organism Enterobacter ludwigii strain D42-sc-1712201

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HWQ18_RS06840 Protein ID WP_121339991.1
Coordinates 1436441..1436725 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A839BTQ9
Locus tag HWQ18_RS06845 Protein ID WP_020885404.1
Coordinates 1436715..1436957 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ18_RS06825 1432756..1433328 + 573 WP_032681842.1 PTS sugar transporter subunit IIA -
HWQ18_RS06830 1433696..1435834 + 2139 WP_121339990.1 anaerobic ribonucleoside-triphosphate reductase -
HWQ18_RS06835 1435973..1436437 + 465 WP_040018491.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HWQ18_RS06840 1436441..1436725 - 285 WP_121339991.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HWQ18_RS06845 1436715..1436957 - 243 WP_020885404.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HWQ18_RS06850 1437035..1438945 - 1911 WP_176586881.1 BglG family transcription antiterminator -
HWQ18_RS06855 1438965..1440101 - 1137 WP_068795278.1 lactonase family protein -
HWQ18_RS06860 1440220..1440960 - 741 WP_014168382.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10918.73 Da        Isoelectric Point: 10.3193

>T162666 WP_121339991.1 NZ_CP056119:c1436725-1436441 [Enterobacter ludwigii]
MTYELVFDPRAFKEWTRLGDTVKNQFKKKLANVLVNPRVESARLHGLPDCDKIKLRSQGYRLVYQVQDNVVTVCVIAIGK
REKSAVYHDVNKRL

Download         Length: 285 bp

>T162666 NZ_CP071954:216153-216260 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9085.49 Da        Isoelectric Point: 5.1088

>AT162666 WP_020885404.1 NZ_CP056119:c1436957-1436715 [Enterobacter ludwigii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDELIQTVRERLANPQKGIKVRLDDL

Download         Length: 243 bp

>AT162666 NZ_CP071954:c216104-216041 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A839BTQ9

References