Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 884286..884906 Replicon chromosome
Accession NZ_CP056119
Organism Enterobacter ludwigii strain D42-sc-1712201

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag HWQ18_RS04235 Protein ID WP_014168902.1
Coordinates 884688..884906 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag HWQ18_RS04230 Protein ID WP_020885187.1
Coordinates 884286..884660 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ18_RS04220 879412..880605 + 1194 WP_032677536.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HWQ18_RS04225 880628..883774 + 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit -
HWQ18_RS04230 884286..884660 + 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
HWQ18_RS04235 884688..884906 + 219 WP_014168902.1 hemolysin expression modulator Hha Toxin
HWQ18_RS04240 885116..885667 + 552 WP_020885188.1 maltose O-acetyltransferase -
HWQ18_RS04245 885785..886252 + 468 WP_020885189.1 extracytoplasmic function sigma factor YlaC -
HWQ18_RS04250 886224..887684 - 1461 WP_176586830.1 PLP-dependent aminotransferase family protein -
HWQ18_RS04255 887785..888495 + 711 WP_014168897.1 GNAT family N-acetyltransferase -
HWQ18_RS04260 888492..888632 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HWQ18_RS04265 888635..888895 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T162665 WP_014168902.1 NZ_CP056119:884688-884906 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

>T162665 NZ_CP071954:160468-160653 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT162665 WP_020885187.1 NZ_CP056119:884286-884660 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp

>AT162665 NZ_CP071954:160670-161080 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGTGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References