Detailed information of TA system TA162654

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1825195..1825913
• Replicon: chromosome
• Accession: NZ_CP056118
• Organism: Enterobacter sp. DSM 30060

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A822WUK4
• Locus tag: HWQ15_RS08670
• Protein ID: WP_071605960.1
• Coordinates: 1825195..1825515 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HWQ15_RS08675
• Protein ID: WP_044599779.1
• Coordinates: 1825557..1825913 (-)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWQ15_RS08635	1821088..1821876	+	789	WP_063148977.1	winged helix-turn-helix domain-containing protein	-
HWQ15_RS08640	1821878..1822357	+	480	WP_022646606.1	hypothetical protein	-
HWQ15_RS08645	1822600..1823481	+	882	WP_038415011.1	helix-turn-helix domain-containing protein	-
HWQ15_RS08650	1823546..1823845	-	300	WP_023299004.1	XRE family transcriptional regulator	-
HWQ15_RS08655	1823969..1824310	-	342	WP_063148976.1	SymE family type I addiction module toxin	-
HWQ15_RS08660	1824438..1824599	+	162	WP_064720300.1	DUF3950 domain-containing protein	-
HWQ15_RS08665	1824712..1824918	-	207	WP_071788007.1	hypothetical protein	-
HWQ15_RS08670	1825195..1825515	-	321	WP_071605960.1	TA system toxin CbtA family protein	Toxin
HWQ15_RS08675	1825557..1825913	-	357	WP_044599779.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HWQ15_RS08680	1825945..1826166	-	222	WP_057696015.1	DUF987 family protein	-
HWQ15_RS08685	1826175..1826645	-	471	WP_023305179.1	DNA repair protein RadC	-
HWQ15_RS08690	1826715..1827536	-	822	WP_044599778.1	DUF945 domain-containing protein	-
HWQ15_RS08695	1827979..1828170	-	192	WP_071605959.1	hypothetical protein	-
HWQ15_RS08700	1828229..1829068	-	840	WP_052735741.1	hypothetical protein	-
HWQ15_RS08705	1829128..1829562	-	435	WP_044599777.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	hcp/tssD	1808957..1847291	38334

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-104)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12227.83 Da
• Isoelectric Point: 6.3229

>T162654 WP_071605960.1 NZ_CP056118:c1825515-1825195 [Enterobacter sp. DSM 30060]
MHISTVPKTVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKSF
SWQDQEPWITSLDVHRAQSNLGLKRP

Nucleotide

• Length: 321 bp

>T162654 NZ_CP071936:c790638-790357 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTACAGAAAGCGA
TATTGCAAGCATTGTTGATTGCCTCAAAGAGCAAAAACCACTCCAACAGAAATATTGCGACCATGCCTTAAGTGGCAATC
TTAAAGGGCTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAAATTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTAA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 13081.91 Da
• Isoelectric Point: 7.7487

>AT162654 WP_044599779.1 NZ_CP056118:c1825913-1825557 [Enterobacter sp. DSM 30060]
MQSTTISGTSAKNTSCLQWGLKRNITPCFGARLVQKGKRLYFLADRAGFNGSFSDAEALSLDQAFPLMVKQLERMLTTGE
LDPHNQHCVTLHHNGLTCEADTLGSYGYVYIAIYPHQL

Nucleotide

• Length: 357 bp

>AT162654 NZ_CP071936:c790945-790631 [Helicobacter pylori]
ATGTCAAATGTTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAAGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACGAATGATCAGACAGG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACGCAAAGCCTGTTAAATACGATTAACTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Structures

Toxin

• AlphaFold DB: A0A822WUK4