162641

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4117743..4118361 Replicon chromosome
Accession NZ_CP056114
Organism Escherichia coli strain Ec394-330266

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HWD38_RS19765 Protein ID WP_001291435.1
Coordinates 4117743..4117961 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HWD38_RS19770 Protein ID WP_000344800.1
Coordinates 4117987..4118361 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWD38_RS19730 (4113030) 4113030..4113602 + 573 WP_000779831.1 YbaY family lipoprotein -
HWD38_RS19735 (4113633) 4113633..4113944 - 312 WP_000409908.1 MGMT family protein -
HWD38_RS19745 (4114323) 4114323..4114676 + 354 WP_000878135.1 DUF1428 family protein -
HWD38_RS19750 (4114718) 4114718..4116268 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HWD38_RS19755 (4116432) 4116432..4116902 - 471 WP_000136192.1 YlaC family protein -
HWD38_RS19760 (4117018) 4117018..4117569 - 552 WP_000102539.1 maltose O-acetyltransferase -
HWD38_RS19765 (4117743) 4117743..4117961 - 219 WP_001291435.1 HHA domain-containing protein Toxin
HWD38_RS19770 (4117987) 4117987..4118361 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HWD38_RS19775 (4118907) 4118907..4122056 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
HWD38_RS19780 (4122079) 4122079..4123272 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T162641 WP_001291435.1 NZ_CP056114:c4117961-4117743 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T162641 NZ_CP071915:c1269995-1269768 [Ralstonia solanacearum]
GTGCGCATCGACCGCCTGCAGATGGGCCACCCGGGCGACATGAAAGCGGTCCGTGACGGCATCCGTGAGCTGCGGATCGA
TCATGGGCCGGGCGACCGCTTGTACTTCGTGCGGCATGGCGTGGTCCTGATCGTACTGCTCTGCGGCGGCGACAAGTCGA
CGCAGGAAACCGATATCCGTCGCGCAATTGACCTGTCCCGCCGTCTCGACGTGGACGACATGGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT162641 WP_000344800.1 NZ_CP056114:c4118361-4117987 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT162641 NZ_CP071915:c1269771-1269466 [Ralstonia solanacearum]
ATGACGATGGCCCAACGCACCATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTCCGGACCGAAGCGGACATCGCCGC
CTACCTCGACGCCTGCCTGGAAGAAGCCGGAGATGACCCCGCCTTCATCACGCATGCGCTGGGCGTGGTCGCGCGCTCGC
GCGGCATGACGCAGCTCGCCCGCGAGACCGGGATGACCCGTGAAGGGCTGTACAAGGCGCTTTCCGAGGGCGGCAATCCG
AGCTTTGCGACCGTGCTGAAGGTCATCCGGGCGCTCGGCATCCGGCTGCACGCCGTGCCGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References