162636

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3377646..3378241 Replicon chromosome
Accession NZ_CP056114
Organism Escherichia coli strain Ec394-330266

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HWD38_RS16200 Protein ID WP_000239579.1
Coordinates 3377891..3378241 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HWD38_RS16195 Protein ID WP_001223208.1
Coordinates 3377646..3377897 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWD38_RS16185 (3373311) 3373311..3377090 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
HWD38_RS16190 (3377093) 3377093..3377434 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HWD38_RS16195 (3377646) 3377646..3377897 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HWD38_RS16200 (3377891) 3377891..3378241 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HWD38_RS16205 (3378321) 3378321..3378851 - 531 WP_000055075.1 inorganic diphosphatase -
HWD38_RS16210 (3379161) 3379161..3380117 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HWD38_RS16215 (3380257) 3380257..3381759 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
HWD38_RS16220 (3381773) 3381773..3382795 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T162636 WP_000239579.1 NZ_CP056114:3377891-3378241 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T162636 NZ_CP071903:1785508-1785762 [Mucilaginibacter rubeus]
ATGGAGATCACAACTTACACTGCCTTCAGGCAGCAACTAAAATCTTTTTTAGATAAGGTGCGGAATGATCATAAGCCTTT
GGTAGTGACAAGTGCCAATGCCGAAGATATTGTTGTGATATCGAAAGCTGATTACGAAAGCATGGAGGAAACTTTCTATC
TTTTAAAAAGCCCTAAAAATGCAGAAAGATTACTTCATGGTATCCAAGAATATGAAAAAGGTTTAGGCAAGGAAAGAAAG
CTACTTGAAGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT162636 WP_001223208.1 NZ_CP056114:3377646-3377897 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT162636 NZ_CP071903:1785759-1786013 [Mucilaginibacter rubeus]
GTGAAGATAATTTTCCAAAACCCTGCATGGGAAGATTACCTTTATTGGCAAACGACAGATAAATCTATTTTAAAGAAGAT
CAACTCTCTTATCAAAGAAATAGAACGAACTCCATATGAAGGAAGTGGAAAGCCCGAACCTTTAAAACATAATTTAGCTG
GTTGGTGGTCGCGCCGGATAAATCTCGAACACAGGCTAATTTACAGAGTAGAAGCAGACGCGATATTTATTCTGCAATGC
AGATATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References