Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2702146..2702981 Replicon chromosome
Accession NZ_CP056114
Organism Escherichia coli strain Ec394-330266

Toxin (Protein)


Gene name yeeV Uniprot ID A0A376WVB1
Locus tag HWD38_RS13030 Protein ID WP_001094448.1
Coordinates 2702604..2702981 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3T7EC32
Locus tag HWD38_RS13025 Protein ID WP_024175935.1
Coordinates 2702146..2702514 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWD38_RS12990 (2697313) 2697313..2698131 + 819 WP_001234753.1 DUF932 domain-containing protein -
HWD38_RS12995 (2698223) 2698223..2698708 + 486 WP_000214415.1 antirestriction protein -
HWD38_RS13000 (2698720) 2698720..2698998 + 279 Protein_2557 hypothetical protein -
HWD38_RS13005 (2699187) 2699187..2700728 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
HWD38_RS13010 (2700743) 2700743..2701489 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
HWD38_RS13015 (2701573) 2701573..2701782 + 210 Protein_2560 hypothetical protein -
HWD38_RS13020 (2701851) 2701851..2702072 + 222 WP_000692346.1 DUF987 domain-containing protein -
HWD38_RS13025 (2702146) 2702146..2702514 + 369 WP_024175935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HWD38_RS13030 (2702604) 2702604..2702981 + 378 WP_001094448.1 TA system toxin CbtA family protein Toxin
HWD38_RS13035 (2702978) 2702978..2703466 + 489 WP_000761714.1 DUF5983 family protein -
HWD38_RS13040 (2703478) 2703478..2703670 + 193 Protein_2565 hypothetical protein -
HWD38_RS13045 (2703755) 2703755..2704600 + 846 WP_000065751.1 DUF4942 domain-containing protein -
HWD38_RS13050 (2705193) 2705193..2705690 + 498 WP_000509815.1 hypothetical protein -
HWD38_RS13055 (2705868) 2705868..2706791 + 924 WP_000535950.1 carboxylate/amino acid/amine transporter -
HWD38_RS13060 (2706795) 2706795..2707613 - 819 WP_000779409.1 lipoprotein NlpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2692029..2705690 13661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14221.22 Da        Isoelectric Point: 8.2919

>T162633 WP_001094448.1 NZ_CP056114:2702604-2702981 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T162633 NZ_CP071898:c6091-5747 [Lactiplantibacillus plantarum]
ATGGTAAGCCAAGGTGATATATTTTATGTTAACTTTAATCCAAGCCGTGGTCATGAACAGATGAATAAGCGACCAGCCAT
TGCGCTAAGCAATGATCTAGTCTGTCAGACAAGTAACATGACGATTGTGGCTCCAATTAGCAGTACCAAGCGTAATTTTC
CAATGTATCATCGACTAACTAGTAGTCAAACAGTATATGGAAAAGTATTATTAGATCAAACCATAGCCTTGGATTTACGG
GCAAGACATGTCACTGATGAAACTATTGTCGATCATGTATCGCGTGAAGAACTAGAAGAAATAATCACTTTGTACAAATT
ATTGTTTAGTATTGATGACAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13598.40 Da        Isoelectric Point: 6.6255

>AT162633 WP_024175935.1 NZ_CP056114:2702146-2702514 [Escherichia coli]
VSDTLSGTTHPDDNDDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT162633 NZ_CP071898:c6348-6085 [Lactiplantibacillus plantarum]
ATGGAACTTATTAAAGAACAAACACGCTTAGCAAAGTGGGGAAACTCGAAAGCTGCTAGAATTCCTAGCCAAATTATTAA
ACAACTGAAATTAGATGATAACCAAGATATGACAATAACCATTGAAAATGGATCAATTGTTTTAACACCAATAAAAAAGA
ACCCAACCAATATTCACGAACTATTTAAGGATTGGCAAGATGACGGGAAAAGGGATCACGAGCTTGATTGGGGAAAGTCA
GAAGGTAATGAACTTCAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376WVB1

Antitoxin

Source ID Structure
AlphaFold DB A0A3T7EC32

References