162632

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2389860..2390660 Replicon chromosome
Accession NZ_CP056114
Organism Escherichia coli strain Ec394-330266

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag HWD38_RS11610 Protein ID WP_000342452.1
Coordinates 2389860..2390387 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag HWD38_RS11615 Protein ID WP_001277107.1
Coordinates 2390394..2390660 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWD38_RS11585 (2384936) 2384936..2385703 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HWD38_RS11590 (2385700) 2385700..2386977 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
HWD38_RS11595 (2386974) 2386974..2387900 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
HWD38_RS11600 (2387948) 2387948..2389057 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
HWD38_RS11605 (2389480) 2389480..2389863 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
HWD38_RS11610 (2389860) 2389860..2390387 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
HWD38_RS11615 (2390394) 2390394..2390660 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
HWD38_RS11620 (2390809) 2390809..2391912 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
HWD38_RS11625 (2392183) 2392183..2393037 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
HWD38_RS11630 (2393282) 2393282..2394340 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
HWD38_RS11635 (2394333) 2394333..2395001 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(88-150)

Antitoxin

(8-86)


Sequences


Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T162632 WP_000342452.1 NZ_CP056114:c2390387-2389860 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

>T162632 NZ_CP071891:4878189-4878440 [Xanthomonas oryzae pv. oryzae]
ATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGATGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGGGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCGGGGTACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT162632 WP_001277107.1 NZ_CP056114:c2390660-2390394 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp

>AT162632 NZ_CP071891:4877884-4878162 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A061K5K9


Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References