Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 1181033..1181562 Replicon plasmid plas1
Accession NZ_CP056086
Organism Ralstonia solanacearum strain FJAT91-F8

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HWE47_RS22795 Protein ID WP_016722340.1
Coordinates 1181033..1181260 (+) Length 76 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HWE47_RS22800 Protein ID WP_016722339.1
Coordinates 1181257..1181562 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWE47_RS22775 1177270..1177869 - 600 WP_016722344.1 GNAT family N-acetyltransferase -
HWE47_RS22780 1178002..1178553 + 552 WP_016722343.1 helix-turn-helix transcriptional regulator -
HWE47_RS22785 1178731..1179552 + 822 WP_011003398.1 GntR family transcriptional regulator -
HWE47_RS22790 1179679..1180878 + 1200 WP_016726513.1 MFS transporter -
HWE47_RS22795 1181033..1181260 + 228 WP_016722340.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HWE47_RS22800 1181257..1181562 + 306 WP_016722339.1 putative addiction module antidote protein Antitoxin
HWE47_RS22805 1181775..1183088 + 1314 WP_038938025.1 metabolite/H+ symporter -
HWE47_RS22810 1183193..1183861 - 669 WP_038938024.1 hypothetical protein -
HWE47_RS22815 1184028..1184245 - 218 Protein_918 transposase -
HWE47_RS22820 1184550..1184834 + 285 WP_011003391.1 hypothetical protein -
HWE47_RS22825 1184965..1185246 + 282 WP_016722336.1 hypothetical protein -
HWE47_RS22830 1185577..1186062 - 486 WP_016726511.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB / acrB / fliI / fliG / fliM / flgG / flgC / cyaB / motA / cheW / cheB / cheY / adeG 1..2000795 2000795
- flank IS/Tn - - 1186297..1187262 965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-67)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-96)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8566.85 Da        Isoelectric Point: 7.2789

>T162613 WP_016722340.1 NZ_CP056086:1181033-1181260 [Ralstonia solanacearum]
VRIDRLQMGHPGNMKAVRDGIRELRIDHGPGDRLYFVRHGVVLIVLLCGGDKSTQETDIRRAIDLSRRLDVDDME

Download         Length: 228 bp

>T162613 NZ_CP071878:c4748077-4747823 [Mucilaginibacter gossypii]
ATGGAGATCACAACTTACACTGCCTTCAGGCAGCAACTAAAATCTTTTTTAGATAAGGTGCGGAATGATCATAAGCCTTT
GGTAGTGACAAGTGCCAATGCCGAAGATATTGTTGTGATATCGAAAGCTGATTACGAAAGCATGGAGGAAACTTTCTATC
TTTTAAAAAGCCCTAAAAATGCAGAAAGATTACTTCATGGTATCCAGGAATATGAAAAAGGTTTAGGCAAGGAAAGAAAG
CTACTTGAAGAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10967.57 Da        Isoelectric Point: 7.2780

>AT162613 WP_016722339.1 NZ_CP056086:1181257-1181562 [Ralstonia solanacearum]
MTMAQRTIKTRPWDSAEHLRTEADIAAYLDACLEEAGDDPAFITHALGVVARSRGMTQLARETGMTREGLYKALSEGGNP
SFATVLKVIRALGIRLHAVPT

Download         Length: 306 bp

>AT162613 NZ_CP071878:c4747826-4747572 [Mucilaginibacter gossypii]
GTGAAGATAATTTTCCAAAACCCTGCATGGGAAGATTACCTTTATTGGCAAACGACAGATAAATCTATTTTAAAGAAGAT
CAACTCTCTTATCAAAGAAATAGAACGAACTCCATATGAAGGAAGTGGAAAGCCCGAACCGTTAAAACATAATTTAGCTG
GTTGGTGGTCGCGCCGGATAAATCTCGAACACAGGCTAATTTACAGAGTAGAAGCAGACGCGATATTTATTCTGCAATGC
AGATATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References