Detailed information of TA system TA162611

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2115138..2116733
• Replicon: chromosome
• Accession: NZ_CP056085
• Organism: Ralstonia solanacearum strain FJAT91-F8

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HWE47_RS09725
• Protein ID: WP_086706272.1
• Coordinates: 2115396..2116733 (+)
• Length: 446 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0S4UDK3
• Locus tag: HWE47_RS09720
• Protein ID: WP_016725279.1
• Coordinates: 2115138..2115392 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWE47_RS09695	2111201..2112127	-	927	WP_016727232.1	muramoyltetrapeptide carboxypeptidase	-
HWE47_RS09700	2112124..2112675	-	552	WP_016727233.1	tRNA adenosine(34) deaminase TadA	-
HWE47_RS09705	2112695..2113171	-	477	WP_011001399.1	6-carboxytetrahydropterin synthase QueD	-
HWE47_RS09710	2113239..2113877	-	639	WP_020831956.1	7-carboxy-7-deazaguanine synthase	-
HWE47_RS09715	2114195..2115034	+	840	WP_011001397.1	oxaloacetate decarboxylase	-
HWE47_RS09720	2115138..2115392	+	255	WP_016725279.1	helix-turn-helix transcriptional regulator	Antitoxin
HWE47_RS09725	2115396..2116733	+	1338	WP_086706272.1	type II toxin-antitoxin system HipA family toxin	Toxin
HWE47_RS09730	2116730..2117932	+	1203	WP_023470034.1	MFS transporter	-
HWE47_RS09735	2118158..2118886	+	729	WP_021155798.1	DsbA family protein	-
HWE47_RS09740	2118899..2119462	-	564	WP_080624831.1	RNA 2',3'-cyclic phosphodiesterase	-
HWE47_RS09745	2119643..2120341	-	699	WP_016725453.1	protocatechuate 3,4-dioxygenase subunit alpha	-
HWE47_RS09750	2120338..2121078	-	741	WP_011001390.1	protocatechuate 3,4-dioxygenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-107)

Antitoxin

• Transcription regulator, HipB-like (10-66)

Sequences

Toxin

Protein

• Length: 446 a.a.
• Molecular weight: 48754.78 Da
• Isoelectric Point: 6.7232

>T162611 WP_086706272.1 NZ_CP056085:2115396-2116733 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDGWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGTSKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Nucleotide

• Length: 1338 bp

>T162611 NZ_CP071876:3432169-3432579 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTGGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCAA
CGCAGGAATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8754.07 Da
• Isoelectric Point: 10.4693

>AT162611 WP_016725279.1 NZ_CP056085:2115138-2115392 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGTPSAA
PADW

Nucleotide

• Length: 255 bp

>AT162611 NZ_CP071876:3431922-3432188 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0S4UDK3