Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1723..2270 Replicon plasmid pMS1170_2
Accession NZ_CP056079
Organism Escherichia coli strain MS1170

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag HED12_RS23160 Protein ID WP_000969996.1
Coordinates 1989..2270 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag HED12_RS23155 Protein ID WP_000079941.1
Coordinates 1723..1992 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HED12_RS23150 1510..1650 + 141 WP_012512742.1 hypothetical protein -
HED12_RS23155 1723..1992 + 270 WP_000079941.1 hypothetical protein Antitoxin
HED12_RS23160 1989..2270 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HED12_RS23165 2316..3164 + 849 WP_001057989.1 3'-5' exonuclease -
HED12_RS23170 3350..5230 + 1881 WP_001610315.1 colicin 1A -
HED12_RS23175 5252..5587 - 336 WP_001080729.1 colicin 1A immunity protein -
HED12_RS23180 5716..5973 + 258 WP_000142431.1 hypothetical protein -
HED12_RS23185 5993..6583 - 591 WP_001350923.1 hypothetical protein -
HED12_RS23190 6580..6840 - 261 WP_000343091.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroN / iroE / iroD / iroC / iroB 1..134406 134406


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T162596 WP_000969996.1 NZ_CP056079:1989-2270 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T162596 NZ_CP071870:c3373115-3372765 [Propioniciclava sp. MC1595]
CTGATGCTCCGCGGTGAGATCCGGTTGGTCGATCTGGAACCTGCCCGCGCAGGAGAGGCGGACAAGCGTAGGCCGGCAGT
CATCGTGAGCAACGACAACGCAAACGCCATCGCAGCCAGGCTGGGTCGAGGCGTCGTCACCGTGGTACCCGTCACCAGCA
ACATCGCGAGGGTCTTCCCCTTCCAGGTCCTCCTCTCCGCTCATGAAACAGGCATCCATGTGGATTCGAAAGCCCAAGCT
GAACAAGTTCGTTCGGTTTCGGTGGCACGACTCGGTCCCGTCATTGGCCGCATTCCCACCCACCTGATGTCCCAACTCGA
CGACGCCCTGCGCCTGCACCTCCAACTCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT162596 WP_000079941.1 NZ_CP056079:1723-1992 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT162596 NZ_CP071870:c3373338-3373099 [Propioniciclava sp. MC1595]
ATGGGTCAGGTGAAGTTGAGTGTGAGTCTCTCCGAGAGCGAGGTCGCAGCCTTGGACAAGTACGCCCACGCTGCTGGCCT
GAAGTCGCGCTCCGCGGCCATCCAGCAGGCGATCAGGCTACTTGGCGACGCAGAACTCCAGACCGCCTACGAAGCTGCTT
GGCAGGAGTGGGAGGACTCGGGTGACGCCGACGCGTGGGATTCCGCCGCTGCCGATGGGCTGGCTGATGCTCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References