Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4429349..4430937 Replicon chromosome
Accession NZ_CP056077
Organism Escherichia coli strain MS1170

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HED12_RS21715 Protein ID WP_096964021.1
Coordinates 4429615..4430937 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V0VAH2
Locus tag HED12_RS21710 Protein ID WP_001304368.1
Coordinates 4429349..4429615 (+) Length 89 a.a.

Genomic Context


HED12_RS21695HED12_RS21700HED12_RS21710HED12_RS21715HED12_RS21720HED12_RS21725HED12_RS21730HED12_RS21705
Location: 4425717..4427168 (1452 bp)
Type: Others
Protein ID: WP_000854637.1
Location: 4427365..4428279 (915 bp)
Type: Others
Protein ID: WP_001313828.1
Location: 4429349..4429615 (267 bp)
Type: Antitoxin
Protein ID: WP_001304368.1
Location: 4429615..4430937 (1323 bp)
Type: Toxin
Protein ID: WP_096964021.1
Location: 4431209..4431475 (267 bp)
Type: Others
Protein ID: Protein_4089
Location: 4431908..4432471 (564 bp)
Type: Others
Protein ID: WP_001296074.1
Location: 4432833..4433543 (711 bp)
Type: Others
Protein ID: WP_001195181.1
Location: 4428283..4429041 (759 bp)
Type: Others
Protein ID: WP_001286588.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HED12_RS216954425717..4427168+1452WP_000854637.1tagaturonate reductase-
HED12_RS217004427365..4428279+915WP_001313828.1bestrophin family inner membrane protein-
HED12_RS217054428283..4429041-759WP_001286588.1trans-aconitate 2-methyltransferase-
HED12_RS217104429349..4429615+267WP_001304368.1type II toxin-antitoxin system antitoxin HipBAntitoxin
HED12_RS217154429615..4430937+1323WP_096964021.1type II toxin-antitoxin system serine/threonine protein kinase toxin HipAToxin
HED12_RS217204431209..4431475+267Protein_4089helix-turn-helix transcriptional regulator-
HED12_RS217254431908..4432471+564WP_001296074.1type 1 fimbrial major subunit FimA-
HED12_RS217304432833..4433543+711WP_001195181.1fimbria/pilus periplasmic chaperone-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(149-401)

Antitoxin

(14-69)


Sequences


Toxin        


Download         Length: 441 a.a.        Molecular weight: 49313.06 Da        Isoelectric Point: 8.6972

>T162594 WP_096964021.1 NZ_CP056077:4429615-4430937 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFLVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

>T162594 NZ_CP071870:1001920-1002201 [Propioniciclava sp. MC1595]
GTGATCGTCTCCTTTGCCGACCGCGATGCCGAACGCCTGTTCCTGCGACAGCGCGTCAAGCGTCTCGACTCTCGTCTGCA
CAAGAAGGCGCTCACAAAGCTGTTGCTACTCGATGCTGCCCACGAGCTTGATGAACTCCGCGTTCCACCGGGGAACCGGC
TGGAAGCACTCAAGGGCGACCGGATCGGTCAGCACAGCATCCGAATCAACGACCAGTGGCGGATCTGCTTCGTCTGGACT
CCTGCGGGCCCCAGCGAGGTTGAGATTGTCGACTATCACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9957.31 Da        Isoelectric Point: 4.9632

>AT162594 WP_001304368.1 NZ_CP056077:4429349-4429615 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW

Download         Length: 267 bp

>AT162594 NZ_CP071870:1002212-1002508 [Propioniciclava sp. MC1595]
ATGGATGACAAGATTCCCCCGATCCATCCGGGCGAGATCCTCATGGAGGAGTTCCTCGTTCCAATGGGCGTAACTCAGAA
CCGGCTGGCAGTATCCATCGGCGTTCCGCCGCGTCGGATCAACGAGATCGTGCACGGCAAGCGTCGGATCACGGCGGATA
CGGCTCTGCGTCTGGGGCGCTTCTACAGCATGAGTGCGCAGTTCTGGATCAACCTGCAGGTGCGCTATGACCTTGAGGTC
GAGATGGACGCCCTCGGGGACGCGCTGGACAGCATTCAGCCGCTACGGACTGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBV0VAH2

References