Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 4429349..4430937 | Replicon | chromosome |
Accession | NZ_CP056077 | ||
Organism | Escherichia coli strain MS1170 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | HED12_RS21715 | Protein ID | WP_096964021.1 |
Coordinates | 4429615..4430937 (+) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | V0VAH2 |
Locus tag | HED12_RS21710 | Protein ID | WP_001304368.1 |
Coordinates | 4429349..4429615 (+) | Length | 89 a.a. |
Genomic Context
Location: 4425717..4427168 (1452 bp)
Type: Others
Protein ID: WP_000854637.1
Type: Others
Protein ID: WP_000854637.1
Location: 4427365..4428279 (915 bp)
Type: Others
Protein ID: WP_001313828.1
Type: Others
Protein ID: WP_001313828.1
Location: 4429349..4429615 (267 bp)
Type: Antitoxin
Protein ID: WP_001304368.1
Type: Antitoxin
Protein ID: WP_001304368.1
Location: 4429615..4430937 (1323 bp)
Type: Toxin
Protein ID: WP_096964021.1
Type: Toxin
Protein ID: WP_096964021.1
Location: 4431209..4431475 (267 bp)
Type: Others
Protein ID: Protein_4089
Type: Others
Protein ID: Protein_4089
Location: 4431908..4432471 (564 bp)
Type: Others
Protein ID: WP_001296074.1
Type: Others
Protein ID: WP_001296074.1
Location: 4432833..4433543 (711 bp)
Type: Others
Protein ID: WP_001195181.1
Type: Others
Protein ID: WP_001195181.1
Location: 4428283..4429041 (759 bp)
Type: Others
Protein ID: WP_001286588.1
Type: Others
Protein ID: WP_001286588.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HED12_RS21695 | 4425717..4427168 | + | 1452 | WP_000854637.1 | tagaturonate reductase | - |
HED12_RS21700 | 4427365..4428279 | + | 915 | WP_001313828.1 | bestrophin family inner membrane protein | - |
HED12_RS21705 | 4428283..4429041 | - | 759 | WP_001286588.1 | trans-aconitate 2-methyltransferase | - |
HED12_RS21710 | 4429349..4429615 | + | 267 | WP_001304368.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
HED12_RS21715 | 4429615..4430937 | + | 1323 | WP_096964021.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
HED12_RS21720 | 4431209..4431475 | + | 267 | Protein_4089 | helix-turn-helix transcriptional regulator | - |
HED12_RS21725 | 4431908..4432471 | + | 564 | WP_001296074.1 | type 1 fimbrial major subunit FimA | - |
HED12_RS21730 | 4432833..4433543 | + | 711 | WP_001195181.1 | fimbria/pilus periplasmic chaperone | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49313.06 Da Isoelectric Point: 8.6972
>T162594 WP_096964021.1 NZ_CP056077:4429615-4430937 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFLVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFLVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
Download Length: 1323 bp
>T162594 NZ_CP071870:1001920-1002201 [Propioniciclava sp. MC1595]
GTGATCGTCTCCTTTGCCGACCGCGATGCCGAACGCCTGTTCCTGCGACAGCGCGTCAAGCGTCTCGACTCTCGTCTGCA
CAAGAAGGCGCTCACAAAGCTGTTGCTACTCGATGCTGCCCACGAGCTTGATGAACTCCGCGTTCCACCGGGGAACCGGC
TGGAAGCACTCAAGGGCGACCGGATCGGTCAGCACAGCATCCGAATCAACGACCAGTGGCGGATCTGCTTCGTCTGGACT
CCTGCGGGCCCCAGCGAGGTTGAGATTGTCGACTATCACTAG
GTGATCGTCTCCTTTGCCGACCGCGATGCCGAACGCCTGTTCCTGCGACAGCGCGTCAAGCGTCTCGACTCTCGTCTGCA
CAAGAAGGCGCTCACAAAGCTGTTGCTACTCGATGCTGCCCACGAGCTTGATGAACTCCGCGTTCCACCGGGGAACCGGC
TGGAAGCACTCAAGGGCGACCGGATCGGTCAGCACAGCATCCGAATCAACGACCAGTGGCGGATCTGCTTCGTCTGGACT
CCTGCGGGCCCCAGCGAGGTTGAGATTGTCGACTATCACTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 9957.31 Da Isoelectric Point: 4.9632
>AT162594 WP_001304368.1 NZ_CP056077:4429349-4429615 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW
Download Length: 267 bp
>AT162594 NZ_CP071870:1002212-1002508 [Propioniciclava sp. MC1595]
ATGGATGACAAGATTCCCCCGATCCATCCGGGCGAGATCCTCATGGAGGAGTTCCTCGTTCCAATGGGCGTAACTCAGAA
CCGGCTGGCAGTATCCATCGGCGTTCCGCCGCGTCGGATCAACGAGATCGTGCACGGCAAGCGTCGGATCACGGCGGATA
CGGCTCTGCGTCTGGGGCGCTTCTACAGCATGAGTGCGCAGTTCTGGATCAACCTGCAGGTGCGCTATGACCTTGAGGTC
GAGATGGACGCCCTCGGGGACGCGCTGGACAGCATTCAGCCGCTACGGACTGCATGA
ATGGATGACAAGATTCCCCCGATCCATCCGGGCGAGATCCTCATGGAGGAGTTCCTCGTTCCAATGGGCGTAACTCAGAA
CCGGCTGGCAGTATCCATCGGCGTTCCGCCGCGTCGGATCAACGAGATCGTGCACGGCAAGCGTCGGATCACGGCGGATA
CGGCTCTGCGTCTGGGGCGCTTCTACAGCATGAGTGCGCAGTTCTGGATCAACCTGCAGGTGCGCTATGACCTTGAGGTC
GAGATGGACGCCCTCGGGGACGCGCTGGACAGCATTCAGCCGCTACGGACTGCATGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
No matching records found |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | V0VAH2 |