Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 1384959..1385660 Replicon chromosome
Accession NZ_CP056077
Organism Escherichia coli strain MS1170

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HED12_RS07300 Protein ID WP_094259026.1
Coordinates 1384959..1385294 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HED12_RS07305 Protein ID WP_096939090.1
Coordinates 1385325..1385660 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HED12_RS07280 1382480..1383277 - 798 WP_001552326.1 helix-turn-helix transcriptional regulator -
HED12_RS07285 1383391..1383666 - 276 WP_001683517.1 type II toxin-antitoxin system RelE/ParE family toxin -
HED12_RS07290 1383670..1383918 - 249 WP_024187601.1 ribbon-helix-helix domain-containing protein -
HED12_RS07295 1383995..1384828 - 834 WP_096939091.1 DUF4942 domain-containing protein -
HED12_RS07300 1384959..1385294 - 336 WP_094259026.1 TA system toxin CbtA family protein Toxin
HED12_RS07305 1385325..1385660 - 336 WP_096939090.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HED12_RS07310 1385660..1386133 - 474 WP_001552321.1 DNA repair protein RadC -
HED12_RS07315 1386163..1386981 - 819 WP_094259024.1 DUF945 domain-containing protein -
HED12_RS07320 1387217..1388170 - 954 WP_094259023.1 hypothetical protein -
HED12_RS07325 1388763..1389377 + 615 WP_094259022.1 inovirus Gp2 family protein -
HED12_RS07330 1389495..1389713 + 219 WP_094259021.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE / fimB 1372211..1400971 28760


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12916.97 Da        Isoelectric Point: 9.7861

>T162578 WP_094259026.1 NZ_CP056077:c1385294-1384959 [Escherichia coli]
MKIIPATTLRATTSYLSPVVVWQILLARLLEQHYGLYLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRRHNTP

Download         Length: 336 bp

>T162578 NZ_CP071861:1035687-1036058 [Enterobacter cloacae]
ATGAATAATATGGCCGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTCGAAGCTGCGGATGCGATTGA
TCATGCCGCGTCACATCGAGCCATTAGCTTAATTACCTGGATGGAGGTGATGGTGGGCGCACGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTGATGGGCGCTTTCGAAATTATTGATGTGTCTCGGGATATCGCGGAAAGAAGCGTTTTACTGCGT
GAAAAGCATGGAATGAAACTGCCTGATGCCATCATTCTGGCCACAGCCCAGAGCAGAAAATGTCCGTTGATTTCTCGAAA
TACGAAAGATTTTTCGGGTATTGATGAGGTCGTTACGCCTTATCAACTGTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12514.48 Da        Isoelectric Point: 7.6977

>AT162578 WP_096939090.1 NZ_CP056077:c1385660-1385325 [Escherichia coli]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPGLMKQLELKLADGELSPCQQR
TVTLYAKGITCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp

>AT162578 NZ_CP071861:1035442-1035684 [Enterobacter cloacae]
ATGAGTGTTTTGGCGGAACTGGATATGGGCAGAATACTGATCGATTTATCTGATGACGTGATTCAACGGCTGGATAACCT
CAAGCAACTGCGAAATCAGCCGCGCGCTGAGCTGCTACGGGAGGCGATAGAGCTGTATCTCGACCAGCAGAGTTCGTCTG
TTATCCGCGCTGCGCTTGGCTTGTGGGGAGACAAGAAAGAAGACGGACTGGAGTATGAACGTAAGCTGCGTGAGGAATGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References