Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2460426..2461064 Replicon chromosome
Accession NZ_CP056073
Organism Escherichia coli strain EC50

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HUS69_RS11810 Protein ID WP_000813794.1
Coordinates 2460888..2461064 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HUS69_RS11805 Protein ID WP_001270286.1
Coordinates 2460426..2460842 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS69_RS11785 (2455578) 2455578..2456519 - 942 WP_001251313.1 ABC transporter permease -
HUS69_RS11790 (2456520) 2456520..2457533 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
HUS69_RS11795 (2457551) 2457551..2458696 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
HUS69_RS11800 (2458941) 2458941..2460347 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
HUS69_RS11805 (2460426) 2460426..2460842 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HUS69_RS11810 (2460888) 2460888..2461064 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HUS69_RS11815 (2461286) 2461286..2461516 + 231 WP_000494244.1 YncJ family protein -
HUS69_RS11820 (2461608) 2461608..2463569 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HUS69_RS11825 (2463642) 2463642..2464178 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
HUS69_RS11830 (2464270) 2464270..2465445 + 1176 WP_232420588.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T162560 WP_000813794.1 NZ_CP056073:c2461064-2460888 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T162560 NZ_CP071852:2123271-2123561 [Vibrio sp. SCSIO 43155]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAATTGTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTGATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT162560 WP_001270286.1 NZ_CP056073:c2460842-2460426 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT162560 NZ_CP071852:2123033-2123281 [Vibrio sp. SCSIO 43155]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTAGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References