Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2356824..2358412 Replicon chromosome
Accession NZ_CP056073
Organism Escherichia coli strain EC50

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag HUS69_RS11335 Protein ID WP_001125439.1
Coordinates 2357090..2358412 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HUS69_RS11330 Protein ID WP_001301023.1
Coordinates 2356824..2357090 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS69_RS11330 (2356824) 2356824..2357090 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HUS69_RS11335 (2357090) 2357090..2358412 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
HUS69_RS11340 (2358724) 2358724..2358932 + 209 Protein_2246 AraC family transcriptional regulator -
HUS69_RS11345 (2359187) 2359187..2360413 + 1227 Protein_2247 fimbria/pilus outer membrane usher protein -
HUS69_RS11350 (2360427) 2360427..2360957 + 531 WP_000876763.1 fimbrial protein -
HUS69_RS11355 (2360970) 2360970..2361473 + 504 WP_000825452.1 fimbrial protein -
HUS69_RS11360 (2361532) 2361532..2362446 + 915 WP_000520676.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T162559 WP_001125439.1 NZ_CP056073:2357090-2358412 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T162559 NZ_CP071852:c2112627-2112325 [Vibrio sp. SCSIO 43155]
ATGGTTGAAGTAATCTGGACAGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATAGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGAGCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAATCAGGTCGTATTCCAC
CCGAACTAGAACATTTAAGTTATCGTGAAGTAGTCGTTAATCCATGTCGTGTCTTCTACAAACAAGACGGTGACAAAGTG
TTTATTCTTTTTGTTATGCGTGCAGAAAGAGATTTACGTAAGTTCTTGTTGAGTAAGCAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT162559 WP_001301023.1 NZ_CP056073:2356824-2357090 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT162559 NZ_CP071852:c2112872-2112615 [Vibrio sp. SCSIO 43155]
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGATACCAAAGAACCAGT
GCTAATTACTGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAACCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGTTGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References