Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 901048..901702 Replicon chromosome
Accession NZ_CP056073
Organism Escherichia coli strain EC50

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag HUS69_RS04330 Protein ID WP_000244777.1
Coordinates 901295..901702 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HUS69_RS04325 Protein ID WP_000354046.1
Coordinates 901048..901314 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS69_RS04300 (896217) 896217..896960 + 744 WP_000951948.1 SDR family oxidoreductase -
HUS69_RS04305 (897017) 897017..898450 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
HUS69_RS04310 (898495) 898495..898806 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
HUS69_RS04315 (898970) 898970..899629 + 660 WP_000250274.1 hemolysin III family protein -
HUS69_RS04320 (899825) 899825..900805 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
HUS69_RS04325 (901048) 901048..901314 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HUS69_RS04330 (901295) 901295..901702 + 408 WP_000244777.1 protein YgfX Toxin
HUS69_RS04335 (901742) 901742..902263 - 522 WP_001055874.1 flavodoxin FldB -
HUS69_RS04340 (902375) 902375..903271 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HUS69_RS04345 (903296) 903296..904006 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUS69_RS04350 (904012) 904012..905745 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T162548 WP_000244777.1 NZ_CP056073:901295-901702 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T162548 NZ_CP071848:1719118-1719396 [Vibrio sp. SCSIO 43136]
ATGATTGTCTGGGAAGAAGAATCTCTAAATGATCGTGAGAAGATCTTTGAATTTCTATACGACTTTAACCCAGCAGCGGC
CGAGAAAACTGATGACCTCATTGAGTCAAAGGTTGAGTGCTCGTTAGAGCAACCATTAATGGGAGTTCAGCGAGATGGAA
TACAAGGCAGGCTGCTTATCATTCCTGAAATTTCGATGATTGTCTCGTACTGGGTTGAGGGTGAGAGCATTCGTATCATG
CGTGTACTCCATCAAAAGCAGAAGTTCCCGATAAGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT162548 WP_000354046.1 NZ_CP056073:901048-901314 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT162548 NZ_CP071848:1718837-1719121 [Vibrio sp. SCSIO 43136]
ATGGACACTAGAATTCAATTTCGTGTTGACGAGGAAACCAAACGTCTAGCCCAGCAAATGGCTGAGAGCCAAGGCCGAAC
ACTTAGTGATGCTTGCCGTGAACTCACTGAGCAACTAGCTGAACAGCAAAGAAAAGCATTATCGCATGATGCTTGGTTGA
CAGAACAGGTAAACCTAGCATTTGAGAAGTATGACTCAGGTAAAGCCGTTTTTATTGACCACGATACAGCAAAGTTGCGA
ATGGAAGAGCGTAAAGCAAGAATTCGTAACCGAGGCAACCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References