Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 906871..907705 Replicon chromosome
Accession NZ_CP056036
Organism Escherichia coli strain EC31

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2T3TJB4
Locus tag HUW39_RS04315 Protein ID WP_000854811.1
Coordinates 906871..907248 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2T3TJJ3
Locus tag HUW39_RS04320 Protein ID WP_001285590.1
Coordinates 907337..907705 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW39_RS04295 (904669) 904669..905889 + 1221 WP_000794251.1 capsular biosynthesis protein -
HUW39_RS04300 (905915) 905915..906145 - 231 Protein_857 hypothetical protein -
HUW39_RS04305 (906251) 906251..906427 - 177 WP_000839288.1 DUF957 domain-containing protein -
HUW39_RS04310 (906444) 906444..906874 - 431 Protein_859 DUF5983 family protein -
HUW39_RS04315 (906871) 906871..907248 - 378 WP_000854811.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
HUW39_RS04320 (907337) 907337..907705 - 369 WP_001285590.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
HUW39_RS04325 (907779) 907779..908000 - 222 WP_000692300.1 DUF987 domain-containing protein -
HUW39_RS04330 (908069) 908069..908545 - 477 WP_001186725.1 RadC family protein -
HUW39_RS04335 (908561) 908561..909046 - 486 WP_000214310.1 antirestriction protein -
HUW39_RS04340 (909138) 909138..909956 - 819 WP_001234593.1 DUF932 domain-containing protein -
HUW39_RS04345 (910074) 910074..910245 - 172 Protein_866 DUF905 family protein -
HUW39_RS04350 (910346) 910346..910801 - 456 WP_000581502.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14041.14 Da        Isoelectric Point: 7.8839

>T162518 WP_000854811.1 NZ_CP056036:c907248-906871 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Download         Length: 378 bp

>T162518 NZ_CP071826:c2022566-2021670 [Burkholderia anthina]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCACGCTGCTCGGGCAGTTTCCCGAGCAGCGCTG
CGAGGCCGGCGCGGCGGGCACGATCGGCTACCGTGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGCGTCAGCTCGACACGCTCGGCGCGTCGCGGCGCGCGCTTGCGTGG
GATGCGCCGGGCTACGGCGTATCGACGCCCGTGCACGGCGCATCGCCGGCGGCCGCCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGCTTGTCCC
GCGCGGTGCCCGCGCGGATCGCCGGCCTGCTGCTGATTTCGCCCGCGGGCGGCTACGGCAGCGCGCCCGCCGAAACGCGC
GACACGCGCCGCGACGCGCGCCTCGCAATGCTCGAGGAGCTCGGCCCGGCCGGGCTCGCCGAGCAGCGGAGCGGCAACAT
GCTGTCCGGTTTCGCGAGCGACGAAGCGCGTGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGTCCGATCTCGCCGGCTTTCGCGGCCGCACGGCGGTGGCGGTCGGC
GCGAACGACGCGATCACGCCGCCGGCTGCCTGCGAGCGCATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
GGCCGGTCATGCCGGTTACGTGGAAGCGCCGGCAGTGTATTCGTCGCTGATCGACGGTTTCTGCCGCCAATGCGATCGTC
AACGGGGGCTGGAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13608.50 Da        Isoelectric Point: 6.6242

>AT162518 WP_001285590.1 NZ_CP056036:c907705-907337 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLYSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT162518 NZ_CP071826:c2021673-2020816 [Burkholderia anthina]
ATGAGCGAACCGTTGCAACGACAGGACGCGGAAAACGCGAAGGCCGAGGCCAACTACGTGGTGCCGGGCCTCGAACGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGCCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAATTACAAG
CTCGGGATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCAACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATTCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACCCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGACGGAGCTGCGTGCGCTGTATCCGGAAGGCGCGCTGAACCGGATGACGAGCGCGAC
GCCGGAGACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGTGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTGGTCACGGCGCCCGTGCGCAACGACACGCAGAGGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGCCCGGAGATCGACGCGTCGCTGATCGCCGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAATTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTGAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T3TJB4

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3TJJ3

References