Detailed information of TA system TA162498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1853838..1854453
• Replicon: chromosome
• Accession: NZ_CP056030
• Organism: Pseudomonas eucalypticola strain NP-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HWQ56_RS08565
• Protein ID: WP_176570221.1
• Coordinates: 1853838..1854020 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HWQ56_RS08570
• Protein ID: WP_176572362.1
• Coordinates: 1854052..1854453 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWQ56_RS08545	1849572..1850192	+	621	WP_158154628.1	2-dehydro-3-deoxy-6-phosphogalactonate aldolase	-
HWQ56_RS08550	1850226..1851374	+	1149	WP_176570218.1	galactonate dehydratase	-
HWQ56_RS08555	1851544..1852854	+	1311	WP_176570219.1	MFS transporter	-
HWQ56_RS08560	1852917..1853750	+	834	WP_176570220.1	IclR family transcriptional regulator	-
HWQ56_RS08565	1853838..1854020	+	183	WP_176570221.1	type II toxin-antitoxin system HicA family toxin	Toxin
HWQ56_RS08570	1854052..1854453	+	402	WP_176572362.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HWQ56_RS08575	1854563..1855753	-	1191	WP_176570222.1	hypothetical protein	-
HWQ56_RS08580	1855750..1859130	-	3381	WP_176570223.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6818.01 Da
• Isoelectric Point: 11.3631

>T162498 WP_176570221.1 NZ_CP056030:1853838-1854020 [Pseudomonas eucalypticola]
MRSREMIRLIMQDGWFLVAVNGSHHPYKHPRKSGRVTIKHPDGDLPKGTINSILKQAGLK

Nucleotide

• Length: 183 bp

>T162498 NZ_CP071819:c4625445-4624912 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCTGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14640.52 Da
• Isoelectric Point: 4.5232

>AT162498 WP_176572362.1 NZ_CP056030:1854052-1854453 [Pseudomonas eucalypticola]
MKFAVVLHKDEDSEYGVIVPDVPGCFSAGTTVTEALESVEQALAFHFEGLVVDGEVLPNPKCIDEHMNNPDYAGGVWAVV
EIDITPYFGKSVRFNATLPEHLLDRIDQTVSRDRRYKSRSGFLAAAALRELSA

Nucleotide

• Length: 402 bp

>AT162498 NZ_CP071819:c4625722-4625456 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
GGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA