Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3850728..3851385 Replicon chromosome
Accession NZ_CP055883
Organism Enterobacter sp. RHBSTW-00975

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag HV340_RS18495 Protein ID WP_014171514.1
Coordinates 3850728..3851138 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HV340_RS18500 Protein ID WP_003863437.1
Coordinates 3851119..3851385 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV340_RS18475 3846726..3848459 - 1734 WP_044866092.1 single-stranded-DNA-specific exonuclease RecJ -
HV340_RS18480 3848465..3849178 - 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV340_RS18485 3849202..3850098 - 897 WP_050737268.1 site-specific tyrosine recombinase XerD -
HV340_RS18490 3850200..3850721 + 522 WP_059306190.1 flavodoxin FldB -
HV340_RS18495 3850728..3851138 - 411 WP_014171514.1 protein YgfX Toxin
HV340_RS18500 3851119..3851385 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HV340_RS18505 3851680..3852660 + 981 WP_020883730.1 tRNA-modifying protein YgfZ -
HV340_RS18510 3852771..3853430 - 660 WP_014171517.1 hemolysin III family protein -
HV340_RS18515 3853697..3854428 + 732 WP_040018863.1 MurR/RpiR family transcriptional regulator -
HV340_RS18520 3854545..3855978 + 1434 WP_020883728.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T162494 WP_014171514.1 NZ_CP055883:c3851138-3850728 [Enterobacter sp. RHBSTW-00975]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T162494 NZ_CP071819:822841-823251 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT162494 WP_003863437.1 NZ_CP055883:c3851385-3851119 [Enterobacter sp. RHBSTW-00975]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT162494 NZ_CP071819:822594-822860 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References