Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1054941..1055561 Replicon chromosome
Accession NZ_CP055883
Organism Enterobacter sp. RHBSTW-00975

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag HV340_RS05115 Protein ID WP_014168902.1
Coordinates 1054941..1055159 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag HV340_RS05120 Protein ID WP_020885187.1
Coordinates 1055187..1055561 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV340_RS05085 1050952..1051212 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
HV340_RS05090 1051215..1051355 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV340_RS05095 1051352..1052062 - 711 WP_014168897.1 GNAT family N-acetyltransferase -
HV340_RS05100 1052163..1053623 + 1461 WP_059305810.1 PLP-dependent aminotransferase family protein -
HV340_RS05105 1053595..1054062 - 468 WP_059305809.1 hypothetical protein -
HV340_RS05110 1054180..1054731 - 552 WP_020885188.1 maltose O-acetyltransferase -
HV340_RS05115 1054941..1055159 - 219 WP_014168902.1 hemolysin expression modulator Hha Toxin
HV340_RS05120 1055187..1055561 - 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
HV340_RS05125 1056073..1059219 - 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit -
HV340_RS05130 1059242..1060435 - 1194 WP_032677536.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T162485 WP_014168902.1 NZ_CP055883:c1055159-1054941 [Enterobacter sp. RHBSTW-00975]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

>T162485 NZ_CP071806:1522879-1523724 [Streptococcus suis]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGTTTAACCTTTAATTCCGTCATGACCTA
TTACTTCCTAGAAGTCATTTTGAAAAAATTAAGTCAGAGTACCTACTCAAATCACTATATCTTCAAAGGGGGGTTTCTGC
TGTCAAATGTTATCGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCAAATGACACTCTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGAGAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAAAAAGAAGACATTGACTTCATTCAGTTGAAAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTTATAACAGTACTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT162485 WP_020885187.1 NZ_CP055883:c1055561-1055187 [Enterobacter sp. RHBSTW-00975]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp

>AT162485 NZ_CP071806:1522292-1522882 [Streptococcus suis]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGCATTATCACCTATAAAGACTGTAAAGCCTTAAA
GATTCCTACAATATATTTGACAAGACTAGAAAAAGAAGGGATTATTTACCGCGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGTTATCCCAAGGCTGTTTTCTCTTATATCTCAGCGCTTTACCTG
CAGCAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCAAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGAACTAGGAATTACACTTGTAAAAACCCCTATGGGAAACGAAGTAA
GAGTGTATGATTTTGAACGCATTATCTGTGATTTTGTCATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTACGGAAACTATTCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACCTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References