Detailed information of TA system TA162484

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 493264..493780
• Replicon: chromosome
• Accession: NZ_CP055883
• Organism: Enterobacter sp. RHBSTW-00975

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV340_RS02365
• Protein ID: WP_047355610.1
• Coordinates: 493496..493780 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A839BTQ9
• Locus tag: HV340_RS02360
• Protein ID: WP_020885404.1
• Coordinates: 493264..493506 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV340_RS02345	489261..490001	+	741	WP_014168382.1	KDGP aldolase family protein	-
HV340_RS02350	490120..491256	+	1137	WP_181216274.1	lactonase family protein	-
HV340_RS02355	491276..493186	+	1911	WP_014168384.1	BglG family transcription antiterminator	-
HV340_RS02360	493264..493506	+	243	WP_020885404.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HV340_RS02365	493496..493780	+	285	WP_047355610.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV340_RS02370	493784..494248	-	465	WP_025205767.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HV340_RS02375	494387..496525	-	2139	WP_181216275.1	anaerobic ribonucleoside-triphosphate reductase	-
HV340_RS02380	496893..497465	-	573	WP_032681842.1	PTS sugar transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10892.65 Da
• Isoelectric Point: 10.1619

>T162484 WP_047355610.1 NZ_CP055883:493496-493780 [Enterobacter sp. RHBSTW-00975]
MTYELVFDPRAFKEWTRLGDTVKNQFKKKLANVLVNPWVESARLHGLPDCDKIKLRSQGYRLVYQVQDNVVTVCVIAIGK
REKSAAYHDANKRL

Nucleotide

• Length: 285 bp

>T162484 NZ_CP071806:c608323-608066 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9085.49 Da
• Isoelectric Point: 5.1088

>AT162484 WP_020885404.1 NZ_CP055883:493264-493506 [Enterobacter sp. RHBSTW-00975]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDELIQTVRERLANPQKGIKVRLDDL

Nucleotide

• Length: 243 bp

>AT162484 NZ_CP071806:c608552-608313 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A839BTQ9