Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 76933..77652 Replicon chromosome
Accession NZ_CP055883
Organism Enterobacter sp. RHBSTW-00975

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1B7K7P6
Locus tag HV340_RS00385 Protein ID WP_023336519.1
Coordinates 76933..77253 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1B7K7N3
Locus tag HV340_RS00390 Protein ID WP_023336520.1
Coordinates 77287..77652 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV340_RS00355 72614..73024 - 411 WP_014168029.1 hydroxyisourate hydrolase -
HV340_RS00360 73124..73849 - 726 WP_014168030.1 MerR family transcriptional regulator -
HV340_RS00365 73967..74491 + 525 WP_020882704.1 lipocalin family protein -
HV340_RS00370 74569..75606 + 1038 WP_059305839.1 hypothetical protein -
HV340_RS00375 75692..75847 - 156 WP_153852750.1 hypothetical protein -
HV340_RS00380 75910..76347 + 438 WP_059305840.1 GNAT family N-acetyltransferase -
HV340_RS00385 76933..77253 - 321 WP_023336519.1 TA system toxin CbtA family protein Toxin
HV340_RS00390 77287..77652 - 366 WP_023336520.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV340_RS00395 77684..77905 - 222 WP_023336521.1 DUF987 domain-containing protein -
HV340_RS00400 77914..78384 - 471 WP_023336522.1 DNA repair protein RadC -
HV340_RS00405 78453..79274 - 822 WP_181216242.1 DUF945 domain-containing protein -
HV340_RS00410 79346..79786 - 441 WP_032645121.1 hypothetical protein -
HV340_RS00415 80031..80834 - 804 WP_023336526.1 hypothetical protein -
HV340_RS00420 80854..81288 - 435 WP_023336527.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 75898..95975 20077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-104)

Antitoxin

Antitoxin CbeA

(18-115)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12166.88 Da        Isoelectric Point: 5.9559

>T162483 WP_023336519.1 NZ_CP055883:c77253-76933 [Enterobacter sp. RHBSTW-00975]
MHIPTVPATVTVSSRLSPVQIWQKLLTYLLEHHYGLTINDTPFSNDTAILEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWLTPLDVHRAQFTLGLKRS

Download         Length: 321 bp

>T162483 NZ_CP071806:461547-462314 [Streptococcus suis]
ATGAGGTTGGAAGAATTTAGTGAGGCTGAGTTTCAGAAGGCTTTACAGCGAACTATTCGAGCCCTAACTCGAGGAAAGAC
GATTCCAGGTCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGAACTCAGCAC
GCAGGGTTATCACTTGCTGATTGAGGGAACTTTGCGAACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGTATCAA
AAGGCTACCAGGTTTCCTTAGCTGTGATTGGCACCAAACCAGAATTGTCCTATCTCAGTACTTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCCAATCAGGCCAGAGTAACGCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTG
CAATTGATGAAGGCTCCGCAGCAGAAGTGTTACAAGAGTGTCTCTTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGATG
AAGGAGGGTAAAAGTAGCTTGAAAAAGTTATATGAAATCAGAGGTTAG

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13481.16 Da        Isoelectric Point: 6.0592

>AT162483 WP_023336520.1 NZ_CP055883:c77652-77287 [Enterobacter sp. RHBSTW-00975]
MQSTTLSGTSAENASCFQWGLKRNITPCFGARLVQEGNRLYFLADRAGFNGSFSDEEALRLDQAFPLMMKQLEQMLTTGE
LDPSSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPWSALTR

Download         Length: 366 bp

>AT162483 NZ_CP071806:461071-461547 [Streptococcus suis]
ATGATTGGAGACAATATTAAATCACTACGTCGGACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCCTGAGCCGTTATGAAAATGGGACTAGTACAGTTTCAACTGAACTCATCGATCGTATTTGTCAAAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGACAAGATGTTAGCACCTGTTGAAGATTACCAACTGACTTTGAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTTTGATGAGTGATGATTTGGCTGAATTGATCAATACAAAGATTTACCTTGTCGATACTTTCGATG
AGATAGAGCGTTACAATGGCTATTTAGACGGTATTGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7K7P6

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7K7N3

References