Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 252928..253450 Replicon plasmid pRHB28-C13_2
Accession NZ_CP055676
Organism Escherichia fergusonii strain RHB28-C13

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag HVY52_RS24145 Protein ID WP_000220561.1
Coordinates 252928..253209 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HVY52_RS24150 Protein ID WP_000121743.1
Coordinates 253199..253450 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY52_RS24115 248404..248640 - 237 Protein_262 hypothetical protein -
HVY52_RS24120 248661..249455 - 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
HVY52_RS24125 249484..250914 - 1431 Protein_264 IS4-like element IS50R family transposase -
HVY52_RS24130 251034..251222 + 189 WP_000957857.1 hypothetical protein -
HVY52_RS24135 251232..252431 + 1200 WP_051124567.1 IS91 family transposase -
HVY52_RS24140 252597..252689 + 93 Protein_267 IS6 family transposase -
HVY52_RS24145 252928..253209 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY52_RS24150 253199..253450 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HVY52_RS24155 254567..255271 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
HVY52_RS24160 255363..255842 + 480 WP_000888203.1 Rrf2 family transcriptional regulator -
HVY52_RS24165 255912..258323 - 2412 Protein_272 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(6)-Id / aph(3'')-Ib / tet(B) / blaTEM-1B / aph(3')-Ia / aac(3)-IVa / aph(4)-Ia / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / tet(A) / dfrA12 / qacE / sul1 / aph(3')-IIa - 1..282651 282651


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T162481 WP_000220561.1 NZ_CP055676:c253209-252928 [Escherichia fergusonii]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T162481 NZ_CP071805:c1804923-1804636 [Bifidobacterium pseudolongum]
ATGGTAACCATCAGCGATTGGGACGCCAGCAAATTCCTCAACAACGAGGACGACATCATCGCGTACCTCAACGCGGTCAT
GGAATACGACGACCCTGCCCTGTTCCAACAGGCCATCGGCAACGTCGCCAAGGCGCGCGGCATGGCACAGGTCGCCAAAG
AGGCGGGCGTGGGGCGCGAAAGCCTGTACAAGAGCCTATCGGCACAGGGGAACCCCTCTTTCCAAACCATCCTGAAAGTC
GTCAAAGCGCTGGGAGGGCGCATCAACATTGAACCCGCAACCGCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT162481 WP_000121743.1 NZ_CP055676:c253450-253199 [Escherichia fergusonii]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT162481 NZ_CP071805:c1805228-1804917 [Bifidobacterium pseudolongum]
ATGGAGGTAAGGACCACAAGCACATATGACACATGGCTCAACAAGCTCAAGGACAGACAGGCGAAGGCCAGGATCATCGC
GAAAACCGACATCATCCAAATGACCGGAACCATCACCGGCGACGTCGAACCCGTGGGCGGCGGCATCAGTGAACTGCGCT
TCCACTTTGGAGGCGGATACCGCATATACTTCGCCCACAAACACAACGAGATAATGTTGCTGATCGCAGGCGGCGACAAA
AGCAGCCAACCCAACGACATCAAACAAGCGCAACAGATACTCGACGCACTGAAAGGACAGCAACTATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References