Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3718227..3718881 Replicon chromosome
Accession NZ_CP055675
Organism Escherichia fergusonii strain RHB28-C13

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag HVY52_RS18110 Protein ID WP_000244781.1
Coordinates 3718227..3718634 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HVY52_RS18115 Protein ID WP_000354046.1
Coordinates 3718615..3718881 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY52_RS18090 3714184..3715917 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
HVY52_RS18095 3715923..3716633 - 711 WP_104917537.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVY52_RS18100 3716658..3717554 - 897 WP_181202809.1 site-specific tyrosine recombinase XerD -
HVY52_RS18105 3717666..3718187 + 522 WP_001055874.1 flavodoxin FldB -
HVY52_RS18110 3718227..3718634 - 408 WP_000244781.1 protein YgfX Toxin
HVY52_RS18115 3718615..3718881 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HVY52_RS18120 3719133..3720113 + 981 WP_181202810.1 tRNA-modifying protein YgfZ -
HVY52_RS18125 3720190..3720849 - 660 WP_000250283.1 hemolysin III family protein -
HVY52_RS18130 3721013..3721324 - 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
HVY52_RS18135 3721369..3722802 + 1434 WP_148047390.1 6-phospho-beta-glucosidase BglA -
HVY52_RS18140 3722850..3723743 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T162472 WP_000244781.1 NZ_CP055675:c3718634-3718227 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T162472 NZ_CP071798:c2335264-2334914 [Sporosarcina sp. Te-1]
TTGGCGATAAAACGTGGAGACGTCTTTTTTGCAGACCTGTCGCCTGTCGTTGGTTCCGAACAGGGCGGTACGAGACCGGT
TCTTGTCATTCAAAATGACATCGGCAACCGGTTCAGTCCGACAGTGATTGTCGCGGCAATCACTGCGCAAATTCAAAAAG
CAAAATTGCCGACACATGTTGAAATCGATGCGGAACGTTATGGATTCGAGCGGGATTCGGTCATCCTGCTCGAGCAAGTT
CGCACAATCGACAAGTCTAGGCTCACAGACAAAATCACCCACTTGGATGAGCAATTGATGGAAAGAGTGGATGAAGCGCT
CGAAGTCAGCTTCGGGTTGATCAAGTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT162472 WP_000354046.1 NZ_CP055675:c3718881-3718615 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT162472 NZ_CP071798:c2335559-2335269 [Sporosarcina sp. Te-1]
GTGCTAGTATTGCGAGAGAAAAAAAACATCAAGGAAGTCATTGTGAAAATCCCTAAGAGGATGTTAACCGAAATTGAACA
TACGGTCGTCCATCAGGAGCCGGAGCGTGAAGAATTCGTGTATGTTTCGACAAAACGCTATGTTACCGATTACGAAGCGG
AAACGATCCGTGAAGTCATGATGAAAGGGTACGTAGAAATGTCGCATATCAACTTGAAAATCGCAAAAGAATGCTTGCAT
GCAGAGCTTGAGGCCCAGCATACGATGGAACGTCTCGTTAGCGGAGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References