Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3441319..3441938 Replicon chromosome
Accession NZ_CP055675
Organism Escherichia fergusonii strain RHB28-C13

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HVY52_RS16750 Protein ID WP_001280991.1
Coordinates 3441720..3441938 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag HVY52_RS16745 Protein ID WP_000344803.1
Coordinates 3441319..3441693 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY52_RS16735 3436451..3437644 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVY52_RS16740 3437667..3440816 + 3150 WP_001132493.1 multidrug efflux RND transporter permease subunit -
HVY52_RS16745 3441319..3441693 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
HVY52_RS16750 3441720..3441938 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HVY52_RS16755 3442433..3442903 + 471 WP_002431406.1 YlaC family protein -
HVY52_RS16760 3443042..3444592 + 1551 WP_181202748.1 EAL domain-containing protein -
HVY52_RS16765 3444634..3444987 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HVY52_RS16775 3445366..3445677 + 312 WP_000409907.1 MGMT family protein -
HVY52_RS16780 3445708..3446280 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T162471 WP_001280991.1 NZ_CP055675:3441720-3441938 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T162471 NZ_CP071797:5817423-5817701 [Pseudomonas fluorescens]
ATGATCAAATCCTTTCAGCACAAAGGCCTTCGCGGCTTCTATGAAACCGGTTCGACTCGCGGGATTCGTGCCGATCACGC
TAAACGGCTGTCGCGCATGCTGCAGTTCATGGATCGCGCAGCGGTTCCGGGGGATCTGGACCTTCCCGGTTGGCGTCTGC
ATCCACTGAAGGGGGAGCTTTGCGAGTACTGGTCGCTCAGTGTGTCCGGGAACTGGCGGGTGATCTTTCGATTTGCAGGT
TCGGATATCGAACTGATCGACTATCTGGATTACCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT162471 WP_000344803.1 NZ_CP055675:3441319-3441693 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT162471 NZ_CP071797:5817716-5818003 [Pseudomonas fluorescens]
ATGCCCATGCACAACCCGCCACACCCCGGTGAAACACTGCTGATGGACGTATTGCCGGAACTTGGCATCAGCGTTACCGA
ATTGGCTCGGCATCTGGGATTCGCTCGTCCTCATCTATCTCGCGTCTTGCACGGACATGCGCCGATCAGCCCGGATCTGG
CTGTACGACTGGAGCGCGCTGGGATTGGCAAGGCTCGTATGTGGCTAGGCGTTCAAACCGATTACGACCTTTGGCAAGCC
GAGCACCGTGAGCAGCCAGCCATTCAACCAATCGCTGCTCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References