Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1412257..1412882 Replicon chromosome
Accession NZ_CP055675
Organism Escherichia fergusonii strain RHB28-C13

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag HVY52_RS06720 Protein ID WP_000911329.1
Coordinates 1412484..1412882 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HVY52_RS06715 Protein ID WP_000450524.1
Coordinates 1412257..1412484 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY52_RS06690 1408059..1408529 - 471 WP_001068688.1 thioredoxin-dependent thiol peroxidase -
HVY52_RS06695 1408529..1409101 - 573 WP_000189057.1 glycine cleavage system transcriptional repressor -
HVY52_RS06700 1409248..1410126 + 879 WP_000494011.1 4-hydroxy-tetrahydrodipicolinate synthase -
HVY52_RS06705 1410143..1411177 + 1035 WP_002431657.1 outer membrane protein assembly factor BamC -
HVY52_RS06710 1411389..1412102 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HVY52_RS06715 1412257..1412484 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HVY52_RS06720 1412484..1412882 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
HVY52_RS06725 1413029..1413892 + 864 WP_001267498.1 neutral zinc metallopeptidase -
HVY52_RS06730 1413907..1415922 + 2016 WP_181203253.1 tRNA cytosine(34) acetyltransferase TmcA -
HVY52_RS06735 1415996..1416697 + 702 WP_105288162.1 esterase -
HVY52_RS06740 1416792..1416992 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T162458 WP_000911329.1 NZ_CP055675:1412484-1412882 [Escherichia fergusonii]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T162458 NZ_CP071796:2445081-2445515 [Ottowia testudinis]
ATGAGCGCCCTTATCTACCTGCTCGACACGAACATTGTCTCGGATGCGATGCGCAACCCCTTCGGGCCGGTGGCGCAGCG
CATTCTGGGGCGCCCAGCCGACGACGGACCAGCGCTGGGCATCAGCGTGGTGGTCGAATGCGAATTGCAGTTTGGCCTGG
CCCGCAAGTCATCGCCCCGCTTGCAAGCGGCCTATGAACCATTGCGCGCGGCGCTGCGCGTCTGGCCGCTCGACGACGCC
GTGCCGCCCCACTACGCCGCCTTGCGTGCCCACCTTGAAACCCAAGGCACCCCCATCGGCCTCAACAACGCCCTGATCGC
CGCCCACGCGCTGGCGCTGGGCGCCACGCTGGTCAGCGGCGATGCCGAATTCGCGCGCGTGCCGGGCCTGAAGGTGGAGA
ACTGGCTCAAGCCTCTGGCCACGCCGGGCGTTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT162458 WP_000450524.1 NZ_CP055675:1412257-1412484 [Escherichia fergusonii]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT162458 NZ_CP071796:2444785-2445084 [Ottowia testudinis]
ATGAGCGCCGTCCCCAACGATCTTCAGCCTGCTGCCGCCCCGCGCCGCGTCAAATTCTTCCGCAATGGCGCCAACCAGGC
GGTGCGCATTCCGCGCGAATTCGAGTTGCCGGGGGATGAAGCGACGGTACGGCGCGAAGGCGACGCGCTCATCATCGAGC
CGGTGGAACCCGTATATCCCAAGGGTTCCGTCGCTGCCTTGCAGCAGGCGCTGCGCAAGCTCCAAGCCCTTGGGCCCATT
GACGAAGAGTTTCCGGACGTGGATGAAGGCCTGCTGCCGCTCGATGACATCGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References