Detailed information of TA system TA162428

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1793578..1794232
• Replicon: chromosome
• Accession: NZ_CP055599
• Organism: Escherichia fergusonii strain RHB41-C23

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: F0JPE9
• Locus tag: HV014_RS08760
• Protein ID: WP_000244774.1
• Coordinates: 1793578..1793985 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HV014_RS08765
• Protein ID: WP_059224144.1
• Coordinates: 1793966..1794232 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV014_RS08740	1789535..1791268	-	1734	WP_000813234.1	single-stranded-DNA-specific exonuclease RecJ	-
HV014_RS08745	1791274..1791984	-	711	WP_104917537.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HV014_RS08750	1792009..1792905	-	897	WP_000806645.1	site-specific tyrosine recombinase XerD	-
HV014_RS08755	1793017..1793538	+	522	WP_001055874.1	flavodoxin FldB	-
HV014_RS08760	1793578..1793985	-	408	WP_000244774.1	protein YgfX	Toxin
HV014_RS08765	1793966..1794232	-	267	WP_059224144.1	FAD assembly factor SdhE	Antitoxin
HV014_RS08770	1794484..1795464	+	981	WP_000886103.1	tRNA-modifying protein YgfZ	-
HV014_RS08775	1795541..1796200	-	660	WP_000250283.1	hemolysin III family protein	-
HV014_RS08780	1796364..1796675	-	312	WP_001182961.1	N(4)-acetylcytidine aminohydrolase	-
HV014_RS08785	1796720..1798153	+	1434	WP_046083325.1	6-phospho-beta-glucosidase BglA	-
HV014_RS08790	1798201..1799094	-	894	WP_000819362.1	transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 16078.05 Da
• Isoelectric Point: 11.2511

>T162428 WP_000244774.1 NZ_CP055599:c1793985-1793578 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Nucleotide

• Length: 408 bp

>T162428 NZ_CP071773:c3542925-3542506 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGTGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAACGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10575.17 Da
• Isoelectric Point: 5.1599

>AT162428 WP_059224144.1 NZ_CP055599:c1794232-1793966 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPVDAELEMMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT162428 NZ_CP071773:c3543155-3542922 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGACAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0L6ZX35