Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 118634..119277 Replicon plasmid unnamed
Accession NZ_CP055510
Organism Klebsiella pneumoniae strain RHBSTW-00472

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag HV207_RS27580 Protein ID WP_001044770.1
Coordinates 118634..119050 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag HV207_RS27585 Protein ID WP_001261282.1
Coordinates 119047..119277 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV207_RS27560 114002..114352 + 351 WP_004187110.1 DUF305 domain-containing protein -
HV207_RS27565 114538..115446 - 909 WP_032451458.1 HNH endonuclease -
HV207_RS27570 115991..117013 - 1023 WP_000361404.1 helicase UvrD -
HV207_RS27575 116998..118560 - 1563 WP_009309907.1 AAA family ATPase -
HV207_RS27580 118634..119050 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
HV207_RS27585 119047..119277 - 231 WP_001261282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HV207_RS27590 119234..119470 + 237 Protein_123 hypothetical protein -
HV207_RS27595 119569..120162 + 594 WP_181247943.1 hypothetical protein -
HV207_RS27600 120181..120621 + 441 WP_047057603.1 hypothetical protein -
HV207_RS27605 120812..121748 - 937 Protein_126 CAAX protease -
HV207_RS27610 122070..122414 + 345 WP_009309911.1 hypothetical protein -
HV207_RS27615 122522..123157 - 636 WP_009309912.1 CPBP family intramembrane metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - mrkJ / mrkF / mrkD / mrkC / mrkB / mrkA 1..333723 333723
- flank IS/Tn - - 112953..113921 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T162411 WP_001044770.1 NZ_CP055510:c119050-118634 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T162411 NZ_CP071770:1455114-1455302 [Acinetobacter towneri]
ATGAACAGCAAAGACATTATTAAGCGTCTTGAGCAGGAAGGCTGGTACAAAGTGGGTGGTAAAGGCGACCATGAAAAGTA
TAAGCATCCTGAAAAGCCTGGACATGTTGTGGTACCACATCCACGTAAAGATATGCCAATAGGAACTCTACGCAATATAT
ATAAACAGGCTGGTTGGGAGTGGAGGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT162411 WP_001261282.1 NZ_CP055510:c119277-119047 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT162411 NZ_CP071770:1455305-1455688 [Acinetobacter towneri]
ATGTTATATCCAGTATATGTTCACAAAGATGAAGATAGCGCATACGGTTTAACCTTTCCTGACTTTGATGGATGCTTTAG
CGCAGCAGATGAGATGCAAGATATTCAGCGCATGGCACAGGAAGCGGTTGAAGTTCACTTTGATGGTGAAGATATTCCGT
TACCAGAACCATCAAGCCCAGAGCAATGGTTAGGTGATGAGCGATTTGAGGGGGGTTTTTGGTTGTTAGTTGATATTGAT
ACAACAAAAGTAAATACAAAGTCTATTCGTATTAATATCAGCATGCCAGAAGCTTTAGTGAAACGTATTGATGCTGTTGC
AAAAAAACAACATTTAAGCCGTTCGGCATTCTTAGCTAAAAGCGCGGAAATGGCGTTGCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References