Detailed information of TA system TA162408

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5018222..5019903
• Replicon: chromosome
• Accession: NZ_CP055509
• Organism: Klebsiella pneumoniae strain RHBSTW-00472

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: HV207_RS24850
• Protein ID: WP_009309420.1
• Coordinates: 5018222..5019139 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: HV207_RS24855
• Protein ID: WP_004177809.1
• Coordinates: 5019145..5019903 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV207_RS24830	5013528..5015048	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
HV207_RS24835	5015045..5016043	+	999	WP_009309413.1	ribose ABC transporter permease	-
HV207_RS24840	5016074..5017015	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
HV207_RS24845	5017090..5018097	+	1008	WP_040212412.1	carbohydrate kinase family protein	-
HV207_RS24850	5018222..5019139	-	918	WP_009309420.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HV207_RS24855	5019145..5019903	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HV207_RS24860	5019989..5020717	-	729	WP_002885152.1	response regulator transcription factor	-
HV207_RS24865	5020990..5023137	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
HV207_RS24870	5023367..5024053	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34738.20 Da
• Isoelectric Point: 5.4746

>T162408 WP_009309420.1 NZ_CP055509:c5019139-5018222 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGEVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVYFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T162408 NZ_CP071770:428375-428623 [Acinetobacter towneri]
ATGGGTAAAACAGAAAAACTGTTGGATAAAATTGGGAATTCAAAAAACACATTTCCGTATAAGGACTTAGTTGTTTTACT
AAGTCAGCTCGGCTATGAAAAGTTTGAAATGGCAGGCTCTCGCGTCCGTTTTTATAACCTTAAAACCGAGCACATGATTT
TACTGCATCGACCTCACCCTGAAAATGAAATCAAAGGTGGGGCATTGAAAGCTGTAAAGCAAGCACTCAAGCAGGAGGGT
TTTTTATGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT162408 WP_004177809.1 NZ_CP055509:c5019903-5019145 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT162408 NZ_CP071770:428620-428955 [Acinetobacter towneri]
ATGAGCTATTTTAAATACAAAGGTTATCTGGGGACGATTGAACCAGACCTTGAAACAGGTGAGTTGTTTGGAAAATTGGC
GTTCATTCGAGATCTTATTACTTATGAGGCTGAAACCTTAAAAACACTTGAGCAAGCTTTTCAGGAATCGGTAGATGGAT
ATTTAGATTCTTGTGCAGAATTAGGGAAGAAACCTGATCAGCCATTCAAGGGAACATTTAATGTTCGTATCAGTCCTGAA
TTACATCGCAAAGCTGTTTTAGCTTCGGAGGAGAGTTCTTTGAATGCATTTGTGAGTGATGCAATTCAAGAGAAATTAAT
GCGCTTAGGTGTATGA

Structures

Antitoxin

• AlphaFold DB: A6TH05