Detailed information of TA system TA162407

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4861603..4862119
• Replicon: chromosome
• Accession: NZ_CP055509
• Organism: Klebsiella pneumoniae strain RHBSTW-00472

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A085DK79
• Locus tag: HV207_RS24050
• Protein ID: WP_009309309.1
• Coordinates: 4861603..4861887 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HV207_RS24055
• Protein ID: WP_009309310.1
• Coordinates: 4861877..4862119 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV207_RS24025	4856998..4857306	-	309	WP_004178377.1	PTS sugar transporter subunit IIB	-
HV207_RS24030	4857391..4857564	+	174	WP_032408826.1	hypothetical protein	-
HV207_RS24035	4857567..4858310	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
HV207_RS24040	4858667..4860805	+	2139	WP_009309308.1	anaerobic ribonucleoside-triphosphate reductase	-
HV207_RS24045	4861135..4861599	+	465	WP_004192393.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HV207_RS24050	4861603..4861887	-	285	WP_009309309.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV207_RS24055	4861877..4862119	-	243	WP_009309310.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HV207_RS24060	4862197..4864107	-	1911	WP_009309311.1	BglG family transcription antiterminator	-
HV207_RS24065	4864130..4865284	-	1155	WP_009309312.1	lactonase family protein	-
HV207_RS24070	4865351..4866091	-	741	WP_009309313.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11141.99 Da
• Isoelectric Point: 10.3787

>T162407 WP_009309309.1 NZ_CP055509:c4861887-4861603 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T162407 NZ_CP071769:c168110-167808 [Acinetobacter towneri]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9067.60 Da
• Isoelectric Point: 8.5547

>AT162407 WP_009309310.1 NZ_CP055509:c4862119-4861877 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLHDL

Nucleotide

• Length: 243 bp

>AT162407 NZ_CP071769:c167807-167526 [Acinetobacter towneri]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Structures

Toxin

• AlphaFold DB: A0A085DK79