Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4802319..4803010 Replicon chromosome
Accession NZ_CP055509
Organism Klebsiella pneumoniae strain RHBSTW-00472

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HV207_RS23785 Protein ID WP_009309816.1
Coordinates 4802319..4802660 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HV207_RS23790 Protein ID WP_009309815.1
Coordinates 4802684..4803010 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV207_RS23760 4797872..4798393 - 522 WP_048983331.1 TetR/AcrR family transcriptional regulator -
HV207_RS23765 4798696..4799676 + 981 WP_009309820.1 adenosine deaminase -
HV207_RS23770 4799673..4800227 + 555 WP_009309819.1 hypothetical protein -
HV207_RS23775 4800227..4801021 + 795 WP_009309818.1 SIR2 family protein -
HV207_RS23780 4801369..4802202 - 834 WP_009309817.1 DUF4942 domain-containing protein -
HV207_RS23785 4802319..4802660 - 342 WP_009309816.1 TA system toxin CbtA family protein Toxin
HV207_RS23790 4802684..4803010 - 327 WP_009309815.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV207_RS23795 4803024..4803500 - 477 WP_009309814.1 DNA repair protein RadC -
HV207_RS23800 4803511..4803957 - 447 WP_009309813.1 antirestriction protein -
HV207_RS23805 4804168..4804857 - 690 WP_009309812.1 hypothetical protein -
HV207_RS23810 4805422..4806273 - 852 WP_009309811.1 50S ribosome-binding GTPase -
HV207_RS23815 4806344..4807312 - 969 WP_074184429.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12900.84 Da        Isoelectric Point: 8.4982

>T162406 WP_009309816.1 NZ_CP055509:c4802660-4802319 [Klebsiella pneumoniae]
MKTLPATTQRAAKPCPSPVTVWQMLLTRLLEQHYGLSLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGF
NCQEQSPYLRAVDILRARQATGLLQYRRNTLSL

Download         Length: 342 bp

>T162406 NZ_CP071769:c167807-167526 [Acinetobacter towneri]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12292.01 Da        Isoelectric Point: 6.6290

>AT162406 WP_009309815.1 NZ_CP055509:c4803010-4802684 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFVDVECQKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQS

Download         Length: 327 bp

>AT162406 NZ_CP071769:c168110-167808 [Acinetobacter towneri]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References