Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4080314..4080933 Replicon chromosome
Accession NZ_CP055509
Organism Klebsiella pneumoniae strain RHBSTW-00472

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HV207_RS20250 Protein ID WP_002892050.1
Coordinates 4080715..4080933 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HV207_RS20245 Protein ID WP_002892066.1
Coordinates 4080314..4080688 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV207_RS20235 4075466..4076659 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV207_RS20240 4076682..4079828 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HV207_RS20245 4080314..4080688 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HV207_RS20250 4080715..4080933 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HV207_RS20255 4081092..4081658 + 567 WP_002892030.1 maltose O-acetyltransferase -
HV207_RS20260 4081630..4081770 - 141 WP_004147370.1 hypothetical protein -
HV207_RS20265 4081791..4082261 + 471 WP_002892026.1 YlaC family protein -
HV207_RS20270 4082236..4083687 - 1452 WP_009307955.1 PLP-dependent aminotransferase family protein -
HV207_RS20275 4083787..4084485 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HV207_RS20280 4084482..4084622 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HV207_RS20285 4084622..4084885 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T162404 WP_002892050.1 NZ_CP055509:4080715-4080933 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T162404 NZ_CP071769:c157074-156781 [Acinetobacter towneri]
ATGACTTATAAGCTTTTACGTCATAAGGACTTCACTGCAGAATGGGAAAAGCTTCCTAGTGCTATACGAGATCAATTCAA
GAAAAAATTAGCTAAGGTAATAGAGCAACCACATATTCCAAAGAATATGCTTAAAGGTGATCTTGCAGGCTGCTATAAAA
TAAAATTATTAAAAGCTGGTGTCCGACTTGTTTACCAGGTCAAAGATGATCAGGTAGTTATTTTGCTAATTACCGTTGGA
AAACGAGCTGATAGCATTGTTTATGATGAAGCAAAAAAGCGGATAAAAGACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT162404 WP_002892066.1 NZ_CP055509:4080314-4080688 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT162404 NZ_CP071769:c157309-157064 [Acinetobacter towneri]
ATGGCTACTGTTAATTTCAGGGTCGATGAAGCCCTTAAAGAAAAGTCTTATTCCATCCTAAAAGAACAAGGAATTGCACC
TACTGAGTTCTTTACTAATATTCTTGAATATATTGCTACGACTGGAAAGCTTCCAGTACAAAAAGCTTTACTCTCAGAGG
AAGATGCTGATTTATTAGCTCTTGTTCGCAAACGTGTTAATGATCCTAAAGAGATGTTCGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References