Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 839112..839769 Replicon chromosome
Accession NZ_CP055509
Organism Klebsiella pneumoniae strain RHBSTW-00472

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HV207_RS04220 Protein ID WP_002916310.1
Coordinates 839359..839769 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HV207_RS04215 Protein ID WP_002916312.1
Coordinates 839112..839378 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV207_RS04190 834268..835701 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HV207_RS04195 835820..836548 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HV207_RS04200 836598..836909 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HV207_RS04205 837073..837732 + 660 WP_002916317.1 hemolysin III family protein -
HV207_RS04210 837883..838866 - 984 WP_009308615.1 tRNA-modifying protein YgfZ -
HV207_RS04215 839112..839378 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HV207_RS04220 839359..839769 + 411 WP_002916310.1 protein YgfX Toxin
HV207_RS04225 839776..840297 - 522 WP_004144730.1 flavodoxin FldB -
HV207_RS04230 840398..841294 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HV207_RS04235 841317..842030 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV207_RS04240 842036..843769 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T162393 WP_002916310.1 NZ_CP055509:839359-839769 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T162393 NZ_CP071767:96527-96829 [Acinetobacter towneri]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTTACTAAGTTAAAAGACCTGCAGGCAAAAAGACGTATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAACCAGTAGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGACCTGGCTACAGGATCTATTACTGTAAGCAAGGGCAAAGGGTCGTTATTCTTTTAGCAGGCGGAGACAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAATTAGCACAAGATTTAGAGGAGGAGCTGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT162393 WP_002916312.1 NZ_CP055509:839112-839378 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT162393 NZ_CP071767:96830-97111 [Acinetobacter towneri]
ATGGCTATCAAACTTCGCAAATGGGACAGTGCTGAACATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCGGCATTCATTGCAAAAGCTTTAGGTAATATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCAAGAGACACTGGTTTAGGTCGAGAAAGTCTTTATAAAGCACTTTCTGGCGATGTAAATCCAAGCTTTGATACTGTT
ATTAAAGTCGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References