Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 758671..759446 Replicon chromosome
Accession NZ_CP055509
Organism Klebsiella pneumoniae strain RHBSTW-00472

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1W1JAQ8
Locus tag HV207_RS03810 Protein ID WP_009308645.1
Coordinates 758961..759446 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag HV207_RS03805 Protein ID WP_004150912.1
Coordinates 758671..758964 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV207_RS03785 753881..754483 - 603 WP_009308651.1 short chain dehydrogenase -
HV207_RS03790 754581..755492 + 912 WP_004188550.1 LysR family transcriptional regulator -
HV207_RS03795 755493..756641 - 1149 WP_004174416.1 PLP-dependent aspartate aminotransferase family protein -
HV207_RS03800 756652..758028 - 1377 WP_009308648.1 cystathionine beta-synthase -
HV207_RS03805 758671..758964 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
HV207_RS03810 758961..759446 + 486 WP_009308645.1 GNAT family N-acetyltransferase Toxin
HV207_RS03815 760044..761024 - 981 WP_014386491.1 IS5-like element ISKpn26 family transposase -
HV207_RS03820 761350..761943 + 594 WP_004188553.1 hypothetical protein -
HV207_RS03825 762040..762256 + 217 Protein_751 transposase -
HV207_RS03835 762771..763484 - 714 WP_009308640.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17595.60 Da        Isoelectric Point: 8.5144

>T162392 WP_009308645.1 NZ_CP055509:758961-759446 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T162392 NZ_CP071767:93963-94253 [Acinetobacter towneri]
ATGGTTAAAGTCGCTGATTTACCAAGTTTTGATATGGCTGAGTCGCTCAAAACTGAAGAAGACATTGTGATGTATCTCAA
TATGGTTCTTGAAGAAAATGATCCAGCTGAATTAGCCCATGCACTTGGTGTTATTGCTAAAGCTCGTGGCATGACTCAAA
TCGCTAAAGAAGCAGGGATTGGGCGTGAAGCACTCTACAAAGCCCTACGTCAGGATTCAGCACCACGTTTTGATACGATT
AATCGTGTAGTAAATGCTTTAGGCTTAAAACTCACAGTACAACACGCTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT162392 WP_004150912.1 NZ_CP055509:758671-758964 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT162392 NZ_CP071767:93665-93961 [Acinetobacter towneri]
ATGATTGAAATTAAACGTCTTCCAGAATTTGATGAATGGTTGGATGGCATTAAAGACAATATGACCCGTATCCGCCTGAA
TCGTCGATTAGATAAGGTTCAACGTGGAAACTGGGGAGACATTAAACCTCTCCAAGATGGCGTTTGGGAAATGAGAGAAT
TCTTCGGTTCTGGATGGAGGATGTATTACATCCAACATGGTGACGTTGTGATTGTAATGCTTGGTGGTGGAGATAAATCA
ACTCAACAACAAGACATCGATCGGGCAGTCAAACTATCGAAAACATTGGAGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W1JAQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References