Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4699308..4699824 Replicon chromosome
Accession NZ_CP055451
Organism Klebsiella pneumoniae strain RHBSTW-00574

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag HV239_RS23065 Protein ID WP_004894697.1
Coordinates 4699308..4699592 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HV239_RS23070 Protein ID WP_002886901.1
Coordinates 4699582..4699824 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV239_RS23040 4694703..4695011 - 309 WP_004894688.1 PTS sugar transporter subunit IIB -
HV239_RS23045 4695096..4695269 + 174 WP_002886906.1 hypothetical protein -
HV239_RS23050 4695272..4696015 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HV239_RS23055 4696372..4698510 + 2139 WP_060416058.1 anaerobic ribonucleoside-triphosphate reductase -
HV239_RS23060 4698840..4699304 + 465 WP_048968808.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HV239_RS23065 4699308..4699592 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV239_RS23070 4699582..4699824 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV239_RS23075 4699902..4701812 - 1911 WP_032412857.1 BglG family transcription antiterminator -
HV239_RS23080 4701835..4702989 - 1155 WP_004178372.1 lactonase family protein -
HV239_RS23085 4703056..4703796 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T162380 WP_004894697.1 NZ_CP055451:c4699592-4699308 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T162380 NZ_CP055451:c4699592-4699308 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTATGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT162380 WP_002886901.1 NZ_CP055451:c4699824-4699582 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT162380 NZ_CP055451:c4699824-4699582 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References