Detailed information of TA system TA162350

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 590952..591471
• Replicon: chromosome
• Accession: NZ_CP055418
• Organism: Citrobacter sp. RHBSTW-00944

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV334_RS02825
• Protein ID: WP_181221150.1
• Coordinates: 591190..591471 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0V9JX71
• Locus tag: HV334_RS02820
• Protein ID: WP_016155558.1
• Coordinates: 590952..591200 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV334_RS02800	586584..587531	+	948	WP_103766891.1	type VI secretion system baseplate subunit TssG	-
HV334_RS02805	587522..590032	+	2511	WP_181221147.1	type VI secretion system ATPase TssH	-
HV334_RS02810	590042..590662	+	621	WP_181221148.1	hypothetical protein	-
HV334_RS02815	590707..590928	+	222	WP_181221149.1	hypothetical protein	-
HV334_RS02820	590952..591200	+	249	WP_016155558.1	hypothetical protein	Antitoxin
HV334_RS02825	591190..591471	+	282	WP_181221150.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV334_RS02830	591498..593462	+	1965	WP_181221151.1	type VI secretion system tip protein VgrG	-
HV334_RS02835	593462..593983	+	522	WP_181221152.1	hypothetical protein	-
HV334_RS02840	594005..594469	-	465	WP_016155562.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10999.74 Da
• Isoelectric Point: 10.2922

>T162350 WP_181221150.1 NZ_CP055418:591190-591471 [Citrobacter sp. RHBSTW-00944]
MTYNLEFLDVALKEWHKLSPTLREQFKKKLAERLENPHVPAARLSGKLHRYKIKLRSAGYRLIYQVEDEQVVVLVIAVGR
RDGDEVYHQANRR

Nucleotide

• Length: 282 bp

>T162350 NZ_CP071750:2407651-2407947 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGAAAAAATTATCGTCGTGGTGTTGTGCGGTGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8987.28 Da
• Isoelectric Point: 4.7513

>AT162350 WP_016155558.1 NZ_CP055418:590952-591200 [Citrobacter sp. RHBSTW-00944]
MPFHILTKTAASITDLKRNPMGTVNAGEGEAVAILNRNEPAFYCVPPAVYAYLLELAEDAELNRIADEREGGKRIKVSLN
DL

Nucleotide

• Length: 249 bp

>AT162350 NZ_CP071750:2407950-2408306 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0V9JX71