Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 129860..130461 Replicon chromosome
Accession NZ_CP055418
Organism Citrobacter sp. RHBSTW-00944

Toxin (Protein)


Gene name doc Uniprot ID H3R940
Locus tag HV334_RS00630 Protein ID WP_006117882.1
Coordinates 130078..130461 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID H3R939
Locus tag HV334_RS00625 Protein ID WP_006117881.1
Coordinates 129860..130081 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV334_RS00600 125275..125847 + 573 WP_058651663.1 3'-5' exoribonuclease -
HV334_RS00605 125844..126698 + 855 WP_058651662.1 Dam family site-specific DNA-(adenine-N6)-methyltransferase -
HV334_RS00610 126695..126979 + 285 WP_058651661.1 hypothetical protein -
HV334_RS00615 127234..129483 + 2250 WP_058651711.1 replication endonuclease -
HV334_RS00620 129494..129679 + 186 WP_058651660.1 hypothetical protein -
HV334_RS00625 129860..130081 + 222 WP_006117881.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HV334_RS00630 130078..130461 + 384 WP_006117882.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HV334_RS00635 130913..131971 - 1059 WP_058651658.1 phage portal protein -
HV334_RS00640 131971..133701 - 1731 WP_063217259.1 terminase family protein -
HV334_RS00645 133861..134697 + 837 WP_058651656.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 121621..152756 31135


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14026.00 Da        Isoelectric Point: 5.5864

>T162348 WP_006117882.1 NZ_CP055418:130078-130461 [Citrobacter sp. RHBSTW-00944]
MKWISAQEVIAFHDRLLAALPGVQGMPEPGRAEAIIYRVQNQLYYEGVEDIHELAAMYLVAISRGHIFNDGNKRTAFFVA
MAFLKRNGIDIRDEGNELEELTVSAATGSLSSGDVAAVLRRLSINPH

Download         Length: 384 bp

>T162348 NZ_CP071750:c1454179-1453958 [Burkholderia pseudomallei]
ATGGAGTGTCGTTGGCGCTTGCAGCGCAACTCGACTGGTCAGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAG
TGAAGTGCGCGAAGTCGGGTTCGGTGTGATCGGCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGC
ACATCATCAGCATGCGTAAGGCGAACAAGCGGGAGGTCAAGAGCTATGTCGAGCAAGCGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8110.06 Da        Isoelectric Point: 5.0644

>AT162348 WP_006117881.1 NZ_CP055418:129860-130081 [Citrobacter sp. RHBSTW-00944]
MRTYTTSQARQNIAEVMEAATAGEPVEITRRDGSAAVLISRDDFNAWQEAKLDAEFAEIMGRHGRTIKALADR

Download         Length: 222 bp

>AT162348 NZ_CP071750:c1453974-1453690 [Burkholderia pseudomallei]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGCCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACGGTGCGCTATGACGTCGACATTGTCGACGCCTTCAAAGCGACGGGCGAAGGTTGGCAGACGCGTATG
AATGATGCGTTGCGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5F1HTY7

Antitoxin

Source ID Structure
AlphaFold DB A0A068Z6U5

References