Detailed information of TA system TA162342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4644184..4645003
• Replicon: chromosome
• Accession: NZ_CP055325
• Organism: Klebsiella michiganensis strain RHBSTW-00409

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: HV187_RS22255
• Protein ID: WP_004110819.1
• Coordinates: 4644746..4645003 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HV187_RS22250
• Protein ID: WP_177340555.1
• Coordinates: 4644184..4644735 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV187_RS22230	4640406..4641314	-	909	WP_009654176.1	transcriptional regulator GcvA	-
HV187_RS22235	4641434..4642321	+	888	WP_009654181.1	DMT family transporter	-
HV187_RS22240	4642539..4643284	-	746	Protein_4372	class I SAM-dependent methyltransferase	-
HV187_RS22245	4643630..4644172	-	543	Protein_4373	class I SAM-dependent methyltransferase	-
HV187_RS22250	4644184..4644735	-	552	WP_177340555.1	N-acetyltransferase	Antitoxin
HV187_RS22255	4644746..4645003	-	258	WP_004110819.1	YjhX family toxin	Toxin
HV187_RS22260	4645679..4646863	+	1185	WP_048261308.1	mannonate dehydratase	-
HV187_RS22265	4646937..4648412	+	1476	WP_009654193.1	fructuronate reductase	-
HV187_RS22270	4648551..4649327	+	777	WP_004847986.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T162342 WP_004110819.1 NZ_CP055325:c4645003-4644746 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T162342 NZ_CP071747:c428040-427771 [Burkholderia pseudomallei]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATTATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20004.83 Da
• Isoelectric Point: 6.4897

>AT162342 WP_177340555.1 NZ_CP055325:c4644735-4644184 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPIMH
ILAPLAVVPEYQGVGVGGGLIRHGIEQLKAMGSQMVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT162342 NZ_CP071747:c427787-427503 [Burkholderia pseudomallei]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGACCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGTAAGCGCGGTCGTCCACCGCTCGAAGCGCCCA
AGGTGCAATTGACGGTGCGCTATGACGTCGACATTGTCGACGCCTTCAAGGCAACGGGAGAAGGCTGGCAGACGCGCATG
AACGATGCGTTGCGCGAGTGGCTGAAGGAGCACCAGCCTGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2