Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 222314..222945 Replicon chromosome
Accession NZ_CP055306
Organism Mannheimia pernigra strain BNO311

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV559_RS00995 Protein ID WP_176807449.1
Coordinates 222314..222712 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HV559_RS01000 Protein ID WP_176807450.1
Coordinates 222712..222945 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV559_RS00975 219147..219413 - 267 WP_176807446.1 chaperone NapD -
HV559_RS00980 219430..219954 - 525 WP_176810358.1 ferredoxin-type protein NapF -
HV559_RS00985 220123..220698 + 576 WP_159628611.1 NAD(P)H-dependent oxidoreductase -
HV559_RS00990 220759..222294 - 1536 WP_176809329.1 L-2,4-diaminobutyrate decarboxylase -
HV559_RS00995 222314..222712 - 399 WP_176807449.1 tRNA(fMet)-specific endonuclease VapC Toxin
HV559_RS01000 222712..222945 - 234 WP_176807450.1 antitoxin Antitoxin
HV559_RS01005 223114..224478 - 1365 WP_176809330.1 diaminobutyrate--2-oxoglutarate transaminase -
HV559_RS01010 224826..224996 - 171 WP_159628615.1 50S ribosomal protein L33 -
HV559_RS01015 225008..225244 - 237 WP_006251446.1 50S ribosomal protein L28 -
HV559_RS01020 225415..226107 - 693 WP_176807453.1 DNA repair protein RadC -
HV559_RS01025 226265..227473 + 1209 WP_176809331.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
HV559_RS01030 227470..227787 + 318 WP_176809332.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14891.17 Da        Isoelectric Point: 8.0586

>T162325 WP_176807449.1 NZ_CP055306:c222712-222314 [Mannheimia pernigra]
MLKYMLDSNIVIYVIKHRPVEVLQRFNQNAGKMCVSSITAAELYYGAEKSGFSARNIAVIEDFLSRLTILDYQPKSAAHF
GNIKAELAKQGKLIGENDIHIAAHARSEGLVIVTNNLREFERVEGLRLENWV

Download         Length: 399 bp

>T162325 NZ_CP071733:c467511-467020 [Bifidobacterium longum subsp. infantis]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTTGATACCAACGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATATCTATCATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCAGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATTGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATAATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCGCTGGAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9009.22 Da        Isoelectric Point: 4.3094

>AT162325 WP_176807450.1 NZ_CP055306:c222945-222712 [Mannheimia pernigra]
MIEASIFMTNRSQAVRLPAEVRFDNDVKKIAVRILGNERILSPLNQSWDSFFLNSETVSEDFMVEREIAMQPEREDF

Download         Length: 234 bp

>AT162325 NZ_CP071733:c467873-467511 [Bifidobacterium longum subsp. infantis]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTATACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATACGTATTACAACATGAAGAGGGCCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References