Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 163748..164267 Replicon chromosome
Accession NZ_CP055305
Organism Mannheimia pernigra strain 17CN0883

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HV560_RS00820 Protein ID WP_176811942.1
Coordinates 163748..164014 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag HV560_RS00825 Protein ID WP_159628595.1
Coordinates 164001..164267 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV560_RS00800 159217..159651 - 435 WP_176811939.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV560_RS00805 159626..160471 - 846 WP_176807426.1 virulence factor BrkB family protein -
HV560_RS00810 160473..161711 - 1239 WP_176811940.1 glutamate-5-semialdehyde dehydrogenase -
HV560_RS00815 161831..163723 + 1893 WP_176811941.1 DNA mismatch repair endonuclease MutL -
HV560_RS00820 163748..164014 - 267 WP_176811942.1 type II toxin-antitoxin system YafQ family toxin Toxin
HV560_RS00825 164001..164267 - 267 WP_159628595.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV560_RS00830 164431..165384 + 954 WP_176812811.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
HV560_RS00835 165455..165730 + 276 WP_176811943.1 RNA chaperone Hfq -
HV560_RS00840 165751..167145 + 1395 WP_176811944.1 GTPase HflX -
HV560_RS00845 167420..168589 - 1170 WP_176807431.1 HlyD family efflux transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10339.89 Da        Isoelectric Point: 6.7013

>T162320 WP_176811942.1 NZ_CP055305:c164014-163748 [Mannheimia pernigra]
MREIEYSNAFKRDYKKCTVDTLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKIDDKLELLRI
GSHSNLFG

Download         Length: 267 bp

>T162320 NZ_CP071731:4506475-4507062 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGAGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9704.13 Da        Isoelectric Point: 4.7863

>AT162320 WP_159628595.1 NZ_CP055305:c164267-164001 [Mannheimia pernigra]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNVETAEVLKAVRNGDEKLNPAKNIADL
MEQLNARD

Download         Length: 267 bp

>AT162320 NZ_CP071731:4507129-4507983 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGCTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGTGAGACGGTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGACAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGTGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References