Detailed information of TA system TA162319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1696706..1697228
• Replicon: chromosome
• Accession: NZ_CP055302
• Organism: Mannheimia pernigra strain 16CN0041

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV561_RS08755
• Protein ID: WP_176808580.1
• Coordinates: 1696938..1697228 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HV561_RS08750
• Protein ID: WP_176808579.1
• Coordinates: 1696706..1696948 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV561_RS08690	1692061..1692537	-	477	WP_176808572.1	DUF1441 family protein	-
HV561_RS08695	1692685..1693083	-	399	WP_176808573.1	hypothetical protein	-
HV561_RS08700	1693220..1693453	-	234	WP_176808574.1	hypothetical protein	-
HV561_RS08705	1693398..1693748	-	351	WP_176808575.1	DUF2570 domain-containing protein	-
HV561_RS08710	1693721..1694260	-	540	WP_176808576.1	lysozyme	-
HV561_RS08715	1694257..1694502	-	246	WP_176808239.1	hypothetical protein	-
HV561_RS08720	1694614..1695189	+	576	WP_176808238.1	hypothetical protein	-
HV561_RS08735	1695476..1695949	-	474	WP_176808577.1	hypothetical protein	-
HV561_RS08740	1695939..1696265	-	327	WP_201723603.1	RusA family crossover junction endodeoxyribonuclease	-
HV561_RS08745	1696304..1696588	-	285	WP_176808578.1	DUF1364 domain-containing protein	-
HV561_RS08750	1696706..1696948	+	243	WP_176808579.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HV561_RS08755	1696938..1697228	+	291	WP_176808580.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV561_RS08760	1697562..1698215	+	654	WP_176808581.1	hypothetical protein	-
HV561_RS08765	1698258..1698708	-	451	Protein_1675	DUF1367 family protein	-
HV561_RS08770	1698827..1699405	-	579	WP_176808582.1	adenine methyltransferase	-
HV561_RS08775	1699402..1700247	-	846	WP_176808583.1	ATP-binding protein	-
HV561_RS11320	1700244..1700990	-	747	WP_202880430.1	replication protein	-
HV561_RS08785	1700987..1701702	-	716	Protein_1679	Rha family transcriptional regulator	-
HV561_RS08790	1701756..1701965	-	210	WP_094945951.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1671947..1741120	69173

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-63)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11325.18 Da
• Isoelectric Point: 10.6516

>T162319 WP_176808580.1 NZ_CP055302:1696938-1697228 [Mannheimia pernigra]
MTYKLVFEEQAFKEWQKLDSSIREQFKKKLTKILANPEIPANKLREIPNGYKIKLRSSGYRLIYQVDNGQIRVLVLAIGK
RERNQAYETAKSRLSH

Nucleotide

• Length: 291 bp

>T162319 NZ_CP071731:c2764525-2764244 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGAAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9266.58 Da
• Isoelectric Point: 4.5580

>AT162319 WP_176808579.1 NZ_CP055302:1696706-1696948 [Mannheimia pernigra]
MATLNVRLDDKLKQQAYAVLADLNISPSEAIRLYFQYITDNRRLPVKQVVLDDEDAELIRIAKHRLENPQGFIEVNLDDL

Nucleotide

• Length: 243 bp

>AT162319 NZ_CP071731:c2764749-2764522 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAAAAGCGCTGGGGGCTGCAATGA