Detailed information of TA system TA162318

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1682369..1682908
• Replicon: chromosome
• Accession: NZ_CP055302
• Organism: Mannheimia pernigra strain 16CN0041

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV561_RS08620
• Protein ID: WP_176808559.1
• Coordinates: 1682369..1682638 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HV561_RS08625
• Protein ID: WP_176808560.1
• Coordinates: 1682642..1682908 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV561_RS08600	1677607..1678323	-	717	WP_176808556.1	phage minor tail protein L	-
HV561_RS08605	1678323..1678651	-	329	Protein_1645	phage tail protein	-
HV561_RS08610	1678651..1681953	-	3303	WP_176808557.1	tape measure protein	-
HV561_RS08615	1682017..1682292	-	276	WP_176808558.1	hypothetical protein	-
HV561_RS08620	1682369..1682638	-	270	WP_176808559.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HV561_RS08625	1682642..1682908	-	267	WP_176808560.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HV561_RS08630	1682972..1683202	-	231	WP_176808561.1	DUF4035 domain-containing protein	-
HV561_RS08635	1683247..1683648	-	402	WP_176808562.1	hypothetical protein	-
HV561_RS08640	1683731..1684372	-	642	WP_176808563.1	hypothetical protein	-
HV561_RS08645	1684404..1684799	-	396	WP_176808564.1	phage tail protein	-
HV561_RS08650	1684796..1685320	-	525	WP_176808565.1	phage tail protein	-
HV561_RS08655	1685327..1685629	-	303	WP_176808566.1	phage tail protein	-
HV561_RS08660	1685622..1685945	-	324	WP_176808567.1	DUF2190 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1671947..1741120	69173

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-77)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10269.94 Da
• Isoelectric Point: 7.3813

>T162318 WP_176808559.1 NZ_CP055302:c1682638-1682369 [Mannheimia pernigra]
MLQISPTNAYKRDFKKIATALVGSSEYVEVMYCLIHQLPLAEKYKDHPLHGEWQGFRDCHIKPDLVLIYAVENNLLRLVR
LGSHSELFG

Nucleotide

• Length: 270 bp

>T162318 NZ_CP071731:c1582415-1582137 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9954.39 Da
• Isoelectric Point: 5.7656

>AT162318 WP_176808560.1 NZ_CP055302:c1682908-1682642 [Mannheimia pernigra]
MATINDAFSFRTNTEIKNIAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETQLAMQEAKSGKNEVYASLND
FHKAMLAE

Nucleotide

• Length: 267 bp

>AT162318 NZ_CP071731:c1582125-1581820 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG